Berti Pierpaolo, Vacca Michele, Bambi Franco, Agostini Vanessa, Bet Nicola, Mascio Maria V, Tripodi Gino, Catalano Liviana, Albiani Roberto, Ventura Marco Della, Montanari Mauro, Costantini Benedetta, Ostuni Angelo, Pignanelli Salvatore, Pollis Francesca, Prati Enrica, Almici Camillo, Tison Tiziana, Villa Stefania, Porzio Ottavia, La Raja Massimo
Transfusion Medicine Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Transfusion Medicine and Cell Therapy Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Blood Transfus. 2025 Mar;23(2):128-136. doi: 10.2450/BloodTransfus.838. Epub 2024 Nov 29.
Adherence to optimal practices in the preparation and issuance of pediatric blood components can significantly influence patient care outcomes. This study aims to examine the blood banking procedures across prominent Italian children's hospitals, with the goal of identifying both consistent and potentially divergent standards within this field.
A survey was conducted among the blood banks affiliated with the Italian Association of Pediatric Hospitals. Modeled after the AABB Neonatal and Pediatric Blood Bank Practices Survey, the questionnaire comprised 25 questions covering hospital characteristics, definitions of the neonatal period, pre-transfusion tests, blood component availability, and irradiation protocols.
Fourteen out of the sixteen invited blood banks participated in the survey. The findings revealed a wide range of practices among the surveyed hospitals. Major differences were noted in the neonatal period definition, pre-transfusion compatibility procedures, and platelet transfusion protocols. All hospitals provided leukodepleted packed red blood cells (pRBCs), with differences in availability of autologous blood and reconstituted whole blood. Irradiated blood components were universally accessible, with differences in post-irradiation acceptable storage time. Additionally, differences in dosages for packed red blood cells (pRBCs) and platelet concentrates (PCs) were observed across hospitals.
Standardized guidelines for pediatric transfusion practices within Italian blood banks are of paramount importance. The observed variability underscores the necessity for sharing best practices among centers supplying blood components to pediatric patients.
在儿科血液成分的制备和发放过程中遵循最佳实践可显著影响患者护理结果。本研究旨在调查意大利著名儿童医院的血库程序，目的是确定该领域内一致和可能存在差异的标准。
对意大利儿科学会附属的血库进行了一项调查。问卷以美国血库协会新生儿和儿科血库实践调查为蓝本，包含25个问题，涵盖医院特征、新生儿期定义、输血前检测、血液成分供应以及辐照方案。
受邀的16家血库中有14家参与了调查。调查结果显示，参与调查的医院做法差异很大。在新生儿期定义、输血前相容性程序和血小板输血方案方面存在重大差异。所有医院均提供白细胞滤除的红细胞悬液（pRBC），自体血和重组全血的供应情况有所不同。辐照血液成分普遍可得，辐照后可接受的储存时间存在差异。此外，各医院间红细胞悬液（pRBC）和血小板浓缩物（PC）的剂量也存在差异。
意大利血库制定儿科输血实践的标准化指南至关重要。观察到的变异性凸显了在为儿科患者供应血液成分的各中心之间分享最佳实践的必要性。
