A new pathway for ferroptosis regulation: The PRMTs.

Protein arginine methyltransferases (PRMTs) play an essential role in the regulation of ferroptosis, a form of programmed cell death characterized by abnormal iron ion metabolism, lipid peroxidation, and DNA damage. Through methylation, PRMTs modify specific proteins, thereby altering their activity, localizations, or interactions with other molecules to control the ferroptosis process. This study was conducted to provide a comprehensive overview of the relationship between PRMTs and ferroptosis, with a focus on the mechanisms by which PRMTs regulate ferroptosis and their effect on this cell death pathway. Currently, only a few studies have been conducted on the regulation of ferroptosis by PRMTs. However, this review provides insights into the effects of PRMTs on ferroptosis regulators, suggesting that the regulation of ferroptosis by PRMTs holds potential as a new therapeutic target for related diseases.