Mann Amy, Kalitsi Jennifer, Jani Khushali, Martins Daniel, Kapoor Ritika R, Paloyelis Yannis
Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, Child and Family Health Nursing, King's College London, London, UK.
Front Neuroendocrinol. 2025 Jan;76:101170. doi: 10.1016/j.yfrne.2024.101170. Epub 2024 Nov 30.
Craniopharyngioma is a benign tumour affecting the hypothalamic and pituitary regions, which are involved in the production and secretion of oxytocin. We conducted a systematic review to assess dysregulation of the oxytocin system in craniopharyngioma and associations with neurobehavioural, eating, and metabolic abnormalities. Eight studies (n = 72 patients) were included. Evidence for dysfunction of the endogenous oxytocin system in craniopharyngioma is limited and mixed. While no significant differences in baseline salivary oxytocin concentrations were reported between patients with craniopharyngioma and controls, patients with craniopharyngioma were found to have blunted salivary oxytocin response following exercise stimulation and this was associated with greater state anxiety and higher BMI. Studies administering exogenous oxytocin are sparse and do not meet required standards. Hypothalamic damage may pose an additional mechanism of oxytocin dysregulation. Improving understanding of the oxytocin system in craniopharyngioma could be pivotal for exploring the potential therapeutic role of exogenous oxytocin in this condition.
颅咽管瘤是一种影响下丘脑和垂体区域的良性肿瘤，而下丘脑和垂体区域参与催产素的产生和分泌。我们进行了一项系统评价，以评估颅咽管瘤中催产素系统的失调情况及其与神经行为、饮食和代谢异常的关联。纳入了八项研究（n = 72例患者）。颅咽管瘤内源性催产素系统功能障碍的证据有限且不一致。虽然未报告颅咽管瘤患者与对照组之间基线唾液催产素浓度有显著差异，但发现颅咽管瘤患者在运动刺激后唾液催产素反应减弱，这与更高的状态焦虑和更高的体重指数相关。给予外源性催产素的研究较少且不符合要求的标准。下丘脑损伤可能是催产素失调的另一种机制。更好地了解颅咽管瘤中的催产素系统可能对探索外源性催产素在这种疾病中的潜在治疗作用至关重要。
