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[对接受手术 + 放疗方案治疗的Ⅰ期和Ⅱ期卵巢癌患者预后因素的评估]

[Evaluation of the prognostic factors in patients with stage-I and -II ovarian cancer treated by an operation + irradiation variant].

作者信息

Tarlowska L, Czesnin K, Psikuta M, Romejko M

出版信息

Vopr Onkol. 1986;32(3):36-44.

PMID:3962255
Abstract

The results of combined treatment (surgery and postoperative radiotherapy) in the group of 240 patients with stage I and II ovarian carcinoma were evaluated. The following factors were found to be important for prognosis: (I) removal of clinically detectable cancer sites during primary surgery (60.7% of 5-year survivals versus 19.4% of cases of surgery described by the surgeon as non-radical); (2) stage of tumor: 62.2% of survivals at stage I as compared with 28.3% at stage II; 73.9% at stage I without changes in the capsule of tumor against 56.9% in the other groups with the same stage; 45.5% at stage IIa versus 22.9% at stages IIb and IIc; (3) low differentiation of ovarian carcinoma which reduces curability to 44.9% in cases of stage I and IIa tumors. Five-year survival rates were higher, though statistically insignificant in those patients with stage Ia(i) and Ib(i) in whom intravaginal radium was applied (81.8%), and in those with stages Ia(ii), Ib(ii) and Ic in whom the whole abdomen was irradiated (64.5%). No statistically significant differences in relation to age, type of surgery, size of tumor identified during the first operation or type of teleradiotherapy (conventional roentgenotherapy or telecobalt therapy) were found.

摘要

对240例I期和II期卵巢癌患者的联合治疗(手术及术后放疗)结果进行了评估。发现以下因素对预后很重要:(1)初次手术时切除临床上可检测到的癌灶(5年生存率为60.7%,而外科医生描述为非根治性手术的病例为19.4%);(2)肿瘤分期:I期生存率为62.2%,II期为28.3%;I期肿瘤包膜无变化者生存率为73.9%,同分期其他组为56.9%;IIa期为45.5%,IIb期和IIc期为22.9%;(3)卵巢癌低分化,I期和IIa期肿瘤患者的治愈率降至44.9%。Ia(i)期和Ib(i)期应用阴道镭疗的患者(81.8%)以及Ia(ii)期、Ib(ii)期和Ic期进行全腹照射的患者5年生存率较高,尽管无统计学意义。在年龄、手术类型、首次手术时发现的肿瘤大小或远距离放射治疗类型(传统X线治疗或钴远距离治疗)方面未发现统计学上的显著差异。

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