Zhavrid E A, Fradkin S Z, Bezruchko V I, Firmanchuk A V, Proleskovskiĭ A K
Vopr Onkol. 1986;32(3):52-7.
Combined and complex treatment for stage II (T3-4N1M0) malignant melanoma of the skin was carried out 111 cases. In 73 of them, local and/or general hyperthermia was employed as cytostatic and radiotherapy modifier. Local super-high frequency hyperthermia was shown to potentiate the antitumor action of ionizing radiation on melanoma cells. Its effect increased with temperature rising from 42 to 43 degrees C. Application of hyperthermia in the said treatment was followed by a considerable increase in 5-year survival, viz. 49.4%. It was significantly higher than with standard treatment procedures (P less than 0.05).
对111例II期（T3 - 4N1M0）皮肤恶性黑色素瘤患者进行了综合及复杂治疗。其中73例采用局部和/或全身热疗作为细胞抑制剂及放疗修饰剂。结果显示，局部超高频热疗可增强电离辐射对黑色素瘤细胞的抗肿瘤作用。随着温度从42摄氏度升至43摄氏度，其效果增强。在上述治疗中应用热疗后，5年生存率显著提高，即49.4%。这明显高于标准治疗程序（P < 0.05）。
