Cui Chengzhi, Cao Jinxing, Liu Jianlan, Zhang Hui
Nanjing Tech University, Nanjing, China.
Nanjing Xiaozhuang University, Nanjing, China.
Drug Deliv Transl Res. 2024 Dec 2. doi: 10.1007/s13346-024-01751-2.
It's crucial of antimicrobial properties in materials is growing as people desire to live healthier. The purpose of this work was to use thermoplastic polyurethane (TPU) as a matrix to produce an antimicrobial material with a tunable drug release rate. Filaments with a diameter of 1.75 ± 0.08 mm were prepared by hot-melt processing technology utilizing TPU, the modifier polyethylene oxide (PEO) and ciprofloxacin hydrochloride monohydrate (CPFX) as raw materials. The corresponding models were then printed using fused deposition type (FDM) 3D printing for performance testing. Results demonstrate the uniform fiber morphology and strong mechanical properties of the four samples, each of which was composed of a different ratio of components. The addition of PEO caused a change to the drug release mechanism, increased the material hydrophilicity, and generated extra pores during the dissolution process. This composite exhibited sustained antimicrobial activity even after 21 days of rotary immersion, as shown by in vitro dissolution and zone inhibition tests.
随着人们希望过上更健康的生活，材料的抗菌性能变得至关重要。这项工作的目的是使用热塑性聚氨酯（TPU）作为基质来生产一种药物释放速率可调的抗菌材料。以TPU、改性剂聚环氧乙烷（PEO）和盐酸环丙沙星一水合物（CPFX）为原料，采用热熔加工技术制备了直径为1.75±0.08mm的长丝。然后使用熔融沉积型（FDM）3D打印对相应模型进行性能测试。结果表明四个样品的纤维形态均匀且机械性能良好，每个样品由不同比例的组分组成。PEO的加入改变了药物释放机制，增加了材料的亲水性，并在溶解过程中产生了额外的孔隙。体外溶出试验和抑菌圈试验表明，即使在旋转浸泡21天后，这种复合材料仍表现出持续的抗菌活性。
