Sabatier Thibaut, Kousignian Isabelle, Gomajee Ramchandar, Barry Katharine M, Melchior Maria, Mary-Krause Murielle
INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), Equipe de Recherche en Epidémiologie Sociale (ERES), Sorbonne Université, Paris, France.
Département d'Epidémiologie et de Promotion de la Santé, CHU de Rouen, Rouen, France.
Subst Use Misuse. 2025;60(4):487-495. doi: 10.1080/10826084.2024.2434674. Epub 2024 Dec 2.
Sleep disturbances (SDs) in childhood can negatively impact behavioral and emotional control, which can lead to an increase in risky behaviors, such as substance use, including alcohol.
Data from 2,132 subjects who participated in the French TEMPO cohort from 1991 to 2018 were used. Sleep disturbances observed from ages 3 to 16 years defined our exposure. Alcohol use in adulthood was measured by alcohol consumption trajectories ascertained by using Group-Based Trajectory Modeling (GBTM) and constitutes our outcomes. The association between sleep disturbances in childhood and alcohol consumption trajectories was studied using multinomial logistic regression.
Sleep disturbances at ≤ 16 years were observed in 26.7% of participants. Three alcohol use trajectories were defined: "light-drinkers", "moderate-drinkers", and "heavy-drinkers". Accounting for many confounders, we found statistically significant associations between sleep disturbances and alcohol use trajectories. Using "light-drinkers" trajectory as reference, we found that compared to children with no sleep disturbances, those with sleep disturbances had a higher likelihood to be in the "moderate-drinkers" (ORa = 1.51; 95% CI = 1.09-2.10) and "heavy-drinkers" trajectory (ORa = 2.34; 95% CI = 1.27-4.34).
This study suggests that sleep disturbances in childhood are associated with an increased risk of higher alcohol consumption in adulthood and highlights the importance of healthy sleep, particularly in children and adolescents, to prevent the onset of certain risky behaviors.
儿童睡眠障碍(SDs)会对行为和情绪控制产生负面影响,进而可能导致危险行为增加,如包括饮酒在内的物质使用。
使用了1991年至2018年参与法国TEMPO队列研究的2132名受试者的数据。3至16岁期间观察到的睡眠障碍定义为我们的暴露因素。成年后的饮酒情况通过基于群体轨迹模型(GBTM)确定的饮酒轨迹来衡量,这构成了我们的研究结果。使用多项逻辑回归研究儿童期睡眠障碍与饮酒轨迹之间的关联。
26.7%的参与者在16岁及以下出现睡眠障碍。定义了三种饮酒轨迹:“轻度饮酒者”、“中度饮酒者”和“重度饮酒者”。在考虑了许多混杂因素后,我们发现睡眠障碍与饮酒轨迹之间存在统计学上的显著关联。以“轻度饮酒者”轨迹为参照,我们发现,与无睡眠障碍的儿童相比,有睡眠障碍的儿童更有可能处于“中度饮酒者”轨迹(优势比a = 1.51;95%置信区间 = 1.09 - 2.10)和“重度饮酒者”轨迹(优势比a = 2.34;95%置信区间 = 1.27 - 4.34)。
本研究表明,儿童期睡眠障碍与成年后饮酒量增加的风险相关,并强调了健康睡眠的重要性,尤其是对儿童和青少年而言,以预防某些危险行为的发生。