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负载碲纳米酶的多功能水凝胶用于脊髓损伤修复

Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair.

作者信息

Meng Jian, Sun Jingjing, Kang Jiali, Ren Shilei, Xu Miaomiao, Li Runzhi, Zhao Xuhui, Yuan Yitong, Xin Lei, Zhang Ruiping

机构信息

Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, Shanxi, China.

The Radiology Department of Shanxi Provincial People' Hospital, Shanxi Medical University, Taiyuan, 030012, China.

出版信息

Mater Today Bio. 2024 Nov 12;29:101339. doi: 10.1016/j.mtbio.2024.101339. eCollection 2024 Dec.

DOI:10.1016/j.mtbio.2024.101339
PMID:39624052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11609504/
Abstract

Spinal cord injury (SCI) results in severe neurological deficits due to disrupted neural pathways. While the spinal cord possesses limited self-repair capabilities, recent advancements in hydrogel-based therapies have shown promise. Polyphenol-based hydrogels, known for their neuroprotective properties, offer a suitable microenvironment for neural regeneration. In this study, a novel poly(lipoic acid)/poly(dopamine) adhesive hydrogel was developed as a versatile platform for delivering therapeutic agents. This hydrogel was loaded with methylcobalamin, a neurotrophic factor, and tellurium nanoenzymes, potent antioxidants. The nanoenzymes effectively mitigated oxidative stress and inflammation, while methylcobalamin promoted nerve regeneration. The combined therapeutic effects of the nanoenzymatic hydrogel demonstrated significant efficacy in repairing spinal cord injuries, highlighting its potential as a promising strategy for treating this debilitating condition.

摘要

脊髓损伤（SCI）由于神经通路中断会导致严重的神经功能缺损。虽然脊髓的自我修复能力有限，但基于水凝胶的疗法最近取得的进展显示出了前景。以其神经保护特性而闻名的基于多酚的水凝胶为神经再生提供了合适的微环境。在这项研究中，一种新型的聚（硫辛酸）/聚（多巴胺）粘性水凝胶被开发出来作为一种用于递送治疗剂的通用平台。这种水凝胶负载了神经营养因子甲钴胺和强效抗氧化剂碲纳米酶。纳米酶有效地减轻了氧化应激和炎症，而甲钴胺促进了神经再生。纳米酶水凝胶的联合治疗效果在修复脊髓损伤方面显示出显著疗效，突出了其作为治疗这种使人衰弱病症的一种有前途策略的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/603b4534e812/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/3d509a518264/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/393228926798/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/0635708224a3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/fe787627b54f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/e3ae6346d8a6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/d72e9b260310/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/603b4534e812/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/3d509a518264/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/393228926798/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/0635708224a3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/fe787627b54f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/e3ae6346d8a6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/d72e9b260310/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b01/11609504/603b4534e812/gr6.jpg

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