Liu Kai, Shao Jiangbo, Han Beibei, Liu Jianfeng, Yan Shuai, Liu Bin, Liu Yao
Department of Hand and Foot Surgery, Orthopedics Center, The First Hospital of Jilin University, Changchun, 130021, China.
Engineering Laboratory of Tissue Engineering Biomaterials of Jilin Province, Changchun, 130021, China.
Mater Today Bio. 2025 Apr 10;32:101755. doi: 10.1016/j.mtbio.2025.101755. eCollection 2025 Jun.
Peripheral nerve regeneration (PNR) represents a substantial challenge in the medical field, primarily due to the limited regenerative capacity of the peripheral nerve system (PNS). Current research efforts are focused on developing advanced medical polymer materials to enhance nerve recovery. Despite significant progress, several critical issues remain unresolved, including biocompatibility, stability, mechanical strength, controlled degradation rates, and sustained release of therapeutic agents. This study examines the utilization of hyaluronic acid hydrogels, doped with mecobalamin (MeCbl) and conductive poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), in combination with exogenous electrical stimulation (ES) for PNR of rats. The strategy utilizes the MeCbl hydrogel to create a regenerative microenvironment and provide nutritional support for nerve cells, while PEDOT:PSS facilitates enhanced electrical signal conduction. ES has been shown to promote PNR and functional recovery, thereby demonstrating considerable potential. This study aims to comprehensively analyze the synergistic effects and potential value of this combined therapeutic approach, providing novel insights and pathways for the effective PNR.
周围神经再生（PNR）是医学领域的一项重大挑战，主要是由于周围神经系统（PNS）的再生能力有限。目前的研究工作集中在开发先进的医用高分子材料以促进神经恢复。尽管取得了重大进展，但仍有几个关键问题尚未解决，包括生物相容性、稳定性、机械强度、可控降解速率以及治疗剂的持续释放。本研究考察了掺杂甲钴胺（MeCbl）和导电聚（3,4-乙撑二氧噻吩）：聚苯乙烯磺酸盐（PEDOT:PSS）的透明质酸水凝胶与外源性电刺激（ES）联合用于大鼠周围神经再生的情况。该策略利用MeCbl水凝胶创造一个再生微环境并为神经细胞提供营养支持，而PEDOT:PSS则有助于增强电信号传导。电刺激已被证明可促进周围神经再生和功能恢复，因此显示出相当大的潜力。本研究旨在全面分析这种联合治疗方法的协同效应和潜在价值，为有效的周围神经再生提供新的见解和途径。
