癌细胞中铁死亡抗性的机制。
Mechanism of ferroptosis resistance in cancer cells.
作者信息
Wang Yuan, Yu Guifang, Chen Xin
机构信息
Key Laboratory of Biological Targeting Diagnosis, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, Guangdong, China.
出版信息
Cancer Drug Resist. 2024 Nov 20;7:47. doi: 10.20517/cdr.2024.127. eCollection 2024.
Ferroptosis is an iron-dependent cell death characterized by increased intracellular lipid peroxidation. Inducing ferroptosis has shown significant potential in eliminating various malignancies. However, the effectiveness of ferroptosis-based treatments is hampered by the intrinsic or acquired resistance of some tumors. In this review, we delineate the known mechanisms that regulate ferroptosis sensitivity and summarize the therapeutic application of ferroptosis inducers in cancer. Additionally, we discuss the roles of diverse signaling pathways that contribute to ferroptosis resistance in cancer cells, including the glutathione (GSH) and coenzyme Q (CoQ) pathways, NFE2-like bZIP transcription factor 2 (NRF2) antioxidant response, and lipid and iron metabolism. This emerging knowledge may serve as a foundation for developing novel anticancer strategies to overcome ferroptosis resistance.
铁死亡是一种铁依赖性细胞死亡，其特征是细胞内脂质过氧化增加。诱导铁死亡在消除各种恶性肿瘤方面已显示出巨大潜力。然而，基于铁死亡的治疗效果受到一些肿瘤的内在或获得性耐药性的阻碍。在这篇综述中，我们阐述了调节铁死亡敏感性的已知机制，并总结了铁死亡诱导剂在癌症中的治疗应用。此外，我们讨论了多种信号通路在癌细胞铁死亡抗性中的作用，包括谷胱甘肽（GSH）和辅酶Q（CoQ）通路、NFE2样bZIP转录因子2（NRF2）抗氧化反应以及脂质和铁代谢。这些新出现的知识可能为开发克服铁死亡抗性的新型抗癌策略奠定基础。
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