González Rodríguez Juan Luis, Oprescu Andreea M, Muñoz Lezcano Sergio, Cordero Ramos Jaime, Romero Cabrera Juan Luis, Armengol de la Hoz Miguel Ángel, Estella Ángel
Big Data Department, Andalusian Public Foundation Progress and Health-FPS, Seville, Spain.
Electronic Technology Department, Universidad de Sevilla, Sevilla, Spain.
Front Public Health. 2024 Nov 18;12:1437388. doi: 10.3389/fpubh.2024.1437388. eCollection 2024.
The global COVID-19 pandemic, caused by the SARS-CoV-2 virus, has presented significant challenges to healthcare systems worldwide.
This study, based on an analysis of a cohort from the Public Health System of Andalusia (Spain), aims to evaluate how vaccination affects case-fatality rate in patients hospitalized due to COVID-19 infection in Andalusia.
The cohort consists of 37,274 individuals after applying the inclusion criteria. We conducted survival analyses employing the Cox proportional hazards models and generated adjusted survival curves to examine the outcomes. The analyses were performed from three perspectives: vaccinated vs. unvaccinated patients, vaccinated and unvaccinated patients grouped by age, and stratified by vaccination status.
Results indicate a substantial correlation between vaccination and a 20% reduction in the risk of case-fatality. Age-specific effects reveal varying degrees of protection across different age groups.
These findings emphasize the pivotal role of vaccination status in COVID-19 risk assessment, supporting the development of a clinical decision support system for accurate predictions and optimizing healthcare management at admission.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒引起的全球新冠肺炎大流行给全球医疗系统带来了重大挑战。
本研究基于对西班牙安达卢西亚公共卫生系统队列的分析，旨在评估疫苗接种如何影响安达卢西亚因新冠肺炎感染住院患者的病死率。
应用纳入标准后，该队列由37274名个体组成。我们采用Cox比例风险模型进行生存分析，并生成调整后的生存曲线以检查结果。分析从三个角度进行：接种疫苗与未接种疫苗的患者、按年龄分组的接种和未接种疫苗的患者，以及按疫苗接种状态分层。
结果表明疫苗接种与病死率风险降低20%之间存在显著相关性。特定年龄效应揭示了不同年龄组的不同保护程度。
这些发现强调了疫苗接种状态在新冠肺炎风险评估中的关键作用，支持开发临床决策支持系统以进行准确预测并优化入院时的医疗管理。
