Moreno-Nunez Paloma, Bueno-Cavanillas Aurora, San Jose-Saras Diego, Vicente-Guijarro Jorge, Fernández Chávez Abelardo Claudio, Aranaz-Andrés Jesús María
Department of Preventive Medicine and Public Health, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain.
J Clin Med. 2022 Jul 5;11(13):3905. doi: 10.3390/jcm11133905.
(1) Background: The development of effective COVID-19 vaccines has reduced the impact of COVID-19 on the general population. Our study aims to analyze how vaccination modifies the likelihood of death and length of stay in hospitalized patients with COVID-19; (2) Methods: A retrospective cohort study of 1927 hospitalized patients infected with COVID-19 was conducted. Information was gathered on vaccination status, hospitalization episode, and clinical profile of the patients. The effect of vaccination on mortality was analyzed using a multiple logistic regression model, and length of stay was analyzed using linear regression. The performance and fit of the models were evaluated; (3) Results: In hospitalized patients with COVID-19, the risk of dying during admission in vaccinated patients was half that of non-vaccinated (OR: 0.45; CI 95%: 0.25 to 0.84). In patients who were discharged due to improvement, the reduction in hospital stay in vaccinated patients was 3.17 days (CI 95%: 5.88 to 0.47); (4) Conclusions: Patients who, despite having been vaccinated, acquire the infection by SARS-CoV-2, have a significant reduction of the risk of death during admission and a reduction of hospital stay compared with unvaccinated patients.
(1) 背景：有效的新冠疫苗的研发降低了新冠疫情对普通人群的影响。我们的研究旨在分析疫苗接种如何改变新冠住院患者的死亡可能性和住院时长；(2) 方法：对1927例新冠感染住院患者进行了一项回顾性队列研究。收集了患者的疫苗接种状况、住院情况及临床特征信息。使用多元逻辑回归模型分析疫苗接种对死亡率的影响，使用线性回归分析住院时长。对模型的性能和拟合度进行了评估；(3) 结果：在新冠住院患者中，接种疫苗患者入院期间的死亡风险是非接种患者的一半（比值比：0.45；95%置信区间：0.25至0.84）。在因病情好转出院的患者中，接种疫苗患者的住院天数减少了3.17天（95%置信区间：5.88至0.47）；(4) 结论：尽管接种了疫苗，但感染了新冠病毒的患者，与未接种疫苗的患者相比，入院期间的死亡风险显著降低，住院时长缩短。
