Sidhanth Y Siva, Bopaiah Harini, Sakalecha Anil Kumar, Dudekula Anees, Prajwal H L Rishi, Punuru Priyanka
Radiodiagnosis, Sri Devaraj Urs Medical College, Kolar, IND.
Radiology, Sri Devaraj Urs Medical College, Kolar, IND.
Cureus. 2024 Nov 1;16(11):e72822. doi: 10.7759/cureus.72822. eCollection 2024 Nov.
Background The corpus callosum (CC) is an important structure of the brain consisting of various parts. The morphometric examination of physiological fluctuations in CC morphology is critical, as these variations may complicate the diagnosis and management of the individual. Therefore, it is important to assess and determine the range of such parameters. Materials and methods An observational, cross-sectional prospective hospital study was carried out over a period of one year, wherein 110 subjects attending our institution were assessed for the mean and range of different parts of the CC across equally distributed males and females, with the help of standardized parameters using MRI. Results The mean anteroposterior (AP) diameter of CC and the mean thickness of the genu, body, isthmus, and splenium were found to be 65.56±8.75 mm, 7.89±2.54 mm, 5.91±1.77 mm, 4.85±1.57 mm, and 8.57±1.92 mm, respectively. The AP diameter shows the greatest variability, with mean values increasing with age, whereas all other parameters such as the thickness of the genu, body, isthmus, and splenium were found to decrease with age. An assessment of these parameters between either gender revealed higher values among males in comparison to that of females, which was found to be statistically significant (p<0.05) across all parameters among the male and female genders. Conclusion The analysis of CC dimensions shows significant variability affected by age and gender. This study offers crucial baseline data on CC morphology, highlighting the important differences between males and females. Recognizing these normal anatomical variations can significantly improve clinical assessments of individuals with potential neurological issues. Further research is needed to investigate the clinical implications of these morphometric differences across different neurological contexts, which may lead to enhanced diagnostic and management approaches for affected individuals.
背景 胼胝体（CC）是大脑的一个重要结构，由不同部分组成。对CC形态的生理波动进行形态测量检查至关重要，因为这些变化可能会使个体的诊断和管理复杂化。因此，评估和确定这些参数的范围很重要。
材料与方法 进行了一项为期一年的观察性横断面前瞻性医院研究，其中借助MRI的标准化参数，对到我院就诊的110名受试者的CC不同部位的均值和范围进行了评估，受试者按性别均匀分布。
结果 发现CC的平均前后径以及膝部、体部、峡部和压部的平均厚度分别为65.56±8.75mm、7.89±2.54mm、5.91±1.77mm、4.85±1.57mm和8.57±1.92mm。前后径显示出最大的变异性，其均值随年龄增加，而所有其他参数，如膝部、体部、峡部和压部的厚度则随年龄减小。对这些参数在不同性别之间的评估显示，男性的值高于女性，在所有参数中，男女之间的差异具有统计学意义（p<0.05）。
结论 CC尺寸分析显示受年龄和性别影响存在显著变异性。本研究提供了关于CC形态的关键基线数据，突出了男性和女性之间的重要差异。认识到这些正常的解剖变异可以显著改善对有潜在神经问题个体的临床评估。需要进一步研究来调查这些形态测量差异在不同神经背景下的临床意义，这可能会导致对受影响个体的诊断和管理方法得到改进。
