Verger K, Junqué C, Levin H S, Jurado M A, Pérez-Gómez M, Bartrés-Faz D, Barrios M, Alvarez A, Bartumeus F, Mercader J M
Department of Psychiatry and Clinical Psychobiology , University of Barcelona, Spain.
Brain Inj. 2001 Mar;15(3):211-21. doi: 10.1080/02699050010004059.
To examine the relationship between neuropsychological sequelae and atrophy parameters from magnetic resonance imaging (MRI) following paediatric moderate-to-severe traumatic brain injury (TBI), 19 head injured children and adolescents were studied at least 6 years after injury. Three-dimensional MRI scans were obtained. A semi-automatic computerized method was used to estimate ventricular volumes and the corpus callosum area. Tests of intellectual, memory, visuospatial, frontal lobe, and motor speed functioning were administered to all patients and to 19 matched normal control subjects. Patients' performance significantly differed from controls in general intellectual function, visual memory, visuospatial and frontal lobe tests. The corpus callosum area correlated strongly with several measures involving processing speed and visuospatial function. Ventricular enlargement was less related to neuropsychological outcome. In conclusion, quantitative measurement of the corpus callosum on MRI reflects neuropsychological outcome better than ventricular dilation in paediatric patients.
为研究小儿中重度创伤性脑损伤（TBI）后神经心理学后遗症与磁共振成像（MRI）萎缩参数之间的关系，对19名头部受伤的儿童和青少年在受伤至少6年后进行了研究。获取了三维MRI扫描图像。采用半自动计算机化方法估计脑室容积和胼胝体面积。对所有患者和19名匹配的正常对照受试者进行了智力、记忆、视觉空间、额叶和运动速度功能测试。患者在一般智力功能、视觉记忆、视觉空间和额叶测试中的表现与对照组有显著差异。胼胝体面积与涉及处理速度和视觉空间功能的多项指标密切相关。脑室扩大与神经心理学结果的相关性较小。总之，在儿科患者中，MRI上胼胝体的定量测量比脑室扩张更能反映神经心理学结果。
