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揭开心脏守护者的面纱:探索褪黑素对心血管系统的影响。

Unlocking the Heart's Guardian: Exploring Melatonin's Impact on the Cardiovascular System.

作者信息

Said Aimen, Shah Darshini, Shah Priyanshi, Singh Bhupinder, Anamika Fnu, Aggarwal Kanishk, Gupta Aachal, Jain Rohit

机构信息

From the Department of Medicine, Marshfield Clinic Health System, Marshfield, WI.

Department of Psychiatry, GCS Medical College, Hospital and Research Centre, Gujarat, India.

出版信息

Cardiol Rev. 2024 Dec 3. doi: 10.1097/CRD.0000000000000822.

Abstract

Melatonin has become a popular choice for managing insomnia and sleep-related issues due to its effectiveness in promoting sleep and its minimal risk of side effects. This has led many individuals to opt for over-the-counter melatonin as an alternative to traditional sleep medications. Recent research indicates that melatonin not only aids in addressing sleep problems but also enhances muscle recovery and performance, thereby improving daytime functioning, particularly among athletes. In the United States, the prevalence of melatonin supplement usage has risen significantly from 0.08% in 2005-2006 to 0.28% in 2017-2018. Individuals with conditions such as heart failure, hypertension, coronary heart disease, and cardiovascular risk factors like diabetes and obesity typically exhibit lower levels of melatonin in their blood at night. This deficiency increases the likelihood of experiencing adverse cardiac events. Studies have highlighted melatonin's role not only in regulating sleep but also in safeguarding against cardiovascular diseases by influencing various cardiovascular functions. In summary, the increasing utilization of melatonin underscores its recognized efficacy in mitigating sleep disturbances, with emerging evidence suggesting potential benefits for cardiovascular health. As ongoing research explores additional therapeutic avenues, the multifaceted impact of melatonin emphasizes its significance in promoting overall well-being.

摘要

褪黑素因其在促进睡眠方面的有效性以及副作用风险极小,已成为治疗失眠和与睡眠相关问题的热门选择。这使得许多人选择非处方褪黑素作为传统睡眠药物的替代品。最近的研究表明,褪黑素不仅有助于解决睡眠问题,还能促进肌肉恢复和提高运动表现,从而改善日间功能,特别是在运动员中。在美国,褪黑素补充剂的使用 prevalence 从2005 - 2006年的0.08%显著上升至2017 - 2018年的0.28%。患有心力衰竭、高血压、冠心病等疾病以及患有糖尿病和肥胖症等心血管危险因素的个体,夜间血液中的褪黑素水平通常较低。这种缺乏增加了发生不良心脏事件的可能性。研究强调了褪黑素不仅在调节睡眠方面的作用,还通过影响各种心血管功能来预防心血管疾病。总之,褪黑素使用的增加凸显了其在减轻睡眠障碍方面公认的疗效,新出现的证据表明其对心血管健康可能有益。随着正在进行的研究探索更多治疗途径,褪黑素的多方面影响强调了其在促进整体健康方面的重要性。

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