Yaslianifard Somayeh, Sameni Fatemeh, Kazemi Kimia, Atefpour Yousef, Hajikhani Bahareh, Baradaran Bagheri Ali, Yazdani Shahrooz, Dadashi Masoud
Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
Ann Clin Microbiol Antimicrob. 2025 Mar 18;24(1):18. doi: 10.1186/s12941-025-00788-6.
Helicobacter pylori (H. pylori) is known to induce chronic inflammatory conditions, and interactions between the host immune system and pathogen have diverted attention toward investigating its correlation with extra-gastrointestinal disorders.
The present study aimed to assess the rate of H. pylori infection in cardiovascular disease (CVD) through a systematic review and meta-analysis.
We conducted a large-scale meta-analysis to determine the prevalence rates of H. pylori infection in vascular diseases. Articles from PubMed/Medline, Web of Science, and Embase databases published between 2000 and 2023 were included for analysis. We used multiple independent observers to extract data, calculated the pooled frequency of H. pylori in vascular diseases using a random effect model, and reported the results as a weighted average based on the study population. The main outcome measures were presented with 95% confidence intervals (CI).
In 87 included studies, the prevalence of H. pylori infection in vascular diseases was 56.7% worldwide. 14.25% of H. pylori isolates harbored the cagA gene. The predominant vascular complication was coronary artery disease (CAD) (31.07%), primarily documented in Europe. This meta-analysis revealed a declining emphasis on studying the association of H. pylori infection with vascular disease in recent times.
According to this meta-analysis, H. pylori infection has a high frequency in CVD and may increase the risk of vascular diseases. However, further research is required, particularly in nations with limited data.
幽门螺杆菌（H. pylori）已知可引发慢性炎症状态，宿主免疫系统与病原体之间的相互作用已将注意力转向研究其与胃肠外疾病的相关性。
本研究旨在通过系统评价和荟萃分析评估心血管疾病（CVD）中幽门螺杆菌感染率。
我们进行了一项大规模荟萃分析，以确定血管疾病中幽门螺杆菌感染的患病率。纳入了2000年至2023年间发表在PubMed/Medline、科学网和Embase数据库上的文章进行分析。我们使用多名独立观察者提取数据，使用随机效应模型计算血管疾病中幽门螺杆菌的合并频率，并根据研究人群将结果报告为加权平均值。主要结局指标以95%置信区间（CI）表示。
在纳入的87项研究中，全球血管疾病中幽门螺杆菌感染的患病率为56.7%。14.25%的幽门螺杆菌分离株携带cagA基因。主要的血管并发症是冠状动脉疾病（CAD）（31.07%），主要记录在欧洲。这项荟萃分析显示，近年来对研究幽门螺杆菌感染与血管疾病关联的重视程度在下降。
根据这项荟萃分析，幽门螺杆菌感染在心血管疾病中发生率较高，可能会增加血管疾病的风险。然而，需要进一步研究，特别是在数据有限的国家。
