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在骨质疏松比格犬模型中使用重组人甲状旁腺激素（1-34）和二聚体甲状旁腺激素（1-34）增强骨再生和骨整合

Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric PTH(1-34) in an osteoporotic beagle model.

作者信息

Shin Jeong-Oh, Lee Jong-Bin, Lee Sihoon, Kim Jin-Woo

机构信息

Department of Anatomy, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.

Department of Periodontology and Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of Korea.

出版信息

Elife. 2024 Dec 3;13:RP93830. doi: 10.7554/eLife.93830.

DOI:10.7554/eLife.93830
PMID:39625374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11614385/
Abstract

This study investigates the effects of two parathyroid hormone (PTH) analogs, rhPTH(1-34) and dimeric PTH(1-34), on bone regeneration and osseointegration in a postmenopausal osteoporosis model using beagle dogs. Twelve osteoporotic female beagles were subjected to implant surgeries and assigned to one of three groups: control, rhPTH(1-34), or dimeric PTH(1-34). Bone regeneration and osseointegration were evaluated after 10 weeks using micro-computed tomographic (micro-CT), histological analyses, and serum biochemical assays. Results showed that the rhPTH(1-34) group demonstrated superior improvements in bone mineral density, trabecular architecture, and osseointegration compared to controls, while the dimeric PTH(1-34) group exhibited similar, though slightly less pronounced, anabolic effects. Histological and TRAP assays indicated both PTH analogs significantly enhanced bone regeneration, especially in artificially created bone defects. The findings suggest that both rhPTH(1-34) and dimeric PTH(1-34) hold potential as therapeutic agents for promoting bone regeneration and improving osseointegration around implants in osteoporotic conditions, with implications for their use in bone-related pathologies and reconstructive surgeries.

摘要

本研究使用比格犬，在绝经后骨质疏松模型中，研究了两种甲状旁腺激素（PTH）类似物，即重组人甲状旁腺激素（1-34）[rhPTH(1-34)]和二聚体PTH(1-34)对骨再生和骨整合的影响。12只骨质疏松的雌性比格犬接受了植入手术，并被分配到三组中的一组：对照组、rhPTH(1-34)组或二聚体PTH(1-34)组。10周后，使用微型计算机断层扫描（micro-CT）、组织学分析和血清生化检测评估骨再生和骨整合情况。结果显示，与对照组相比，rhPTH(1-34)组在骨矿物质密度、小梁结构和骨整合方面表现出更优的改善，而二聚体PTH(1-34)组表现出相似但稍弱的合成代谢作用。组织学和抗酒石酸酸性磷酸酶（TRAP）检测表明，两种PTH类似物均显著增强了骨再生，尤其是在人工制造的骨缺损处。研究结果表明，rhPTH(1-34)和二聚体PTH(1-34)都有潜力作为治疗药物，用于促进骨质疏松症患者的骨再生和改善植入物周围的骨整合，这对它们在骨相关疾病和重建手术中的应用具有启示意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/20c463247878/elife-93830-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/5411401e5ab4/elife-93830-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/4e16da65976c/elife-93830-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/6091a89b631c/elife-93830-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/1f67dea03d60/elife-93830-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/ecda2421ff31/elife-93830-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/20c463247878/elife-93830-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/5411401e5ab4/elife-93830-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/4e16da65976c/elife-93830-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/6091a89b631c/elife-93830-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/1f67dea03d60/elife-93830-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/ecda2421ff31/elife-93830-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/11614385/20c463247878/elife-93830-fig5.jpg

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