甲状旁腺激素（1-34）经系统给药和唑来膦酸吸附在种植体表面促进种植体周围骨愈合。
Promotion of peri-implant bone healing by systemically administered parathyroid hormone (1-34) and zoledronic acid adsorbed onto the implant surface.
机构信息
State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No 14, Section 3, Southern Renmin Road, Chengdu 610041, China.
出版信息
Osteoporos Int. 2013 Mar;24(3):1063-71. doi: 10.1007/s00198-012-2258-5. Epub 2013 Jan 8.
UNLABELLED
The effect of human parathyroid hormone 1-34 (PTH) and zoledronic acid (ZA) alone or in combination on bone healing in osteoporotic settings was tested using implants inserted in tibiae of ovariectomized (OVX) rats. Combination therapy promoted bone healing more than each treatment alone 12 weeks after implant insertion.
INTRODUCTION
PTH and ZA have been demonstrated to be effective on implant fixation. However, reports about the combined use of PTH and ZA for promotion of bone healing around implant in osteoporotic settings are still limited. This study aims to investigate effects of PTH+ZA on implant stabilization in OVX rats.
METHODS
Twelve weeks after bilateral ovariectomy, OVX rats randomly received implants without or with ZA (by immersion in 1 mg/ml ZA solution for 24 h). Subsequently, half of the animals from each group also received subcutaneous injections of PTH (60 μg/kg, three times a week) for 12 weeks. Thus, there were four groups: control, PTH, ZA, and PTH+ZA.
RESULTS
All treatments promoted bone healing around implant compared to control, but PTH+ZA treatment showed significantly stronger effects than PTH or ZA alone in histological, micro-CT, and biomechanical tests.
CONCLUSION
The results indicated the additive effects of PTH and ZA on implant fixation in OVX rats; it was suggested that the anabolic effect of PTH was potent and not blunted by ZA during bone healing around implant when used concurrently.
目的
在骨质疏松环境中，使用植入物插入去卵巢（OVX）大鼠的胫骨中，测试人甲状旁腺激素 1-34（PTH）和唑来膦酸（ZA）单独或联合使用对骨愈合的影响。
方法
OVX 后 12 周，将 OVX 大鼠随机分为未植入组、植入组、植入+ZA 组和植入+PTH 组，每组 10 只。
结果
与对照组相比，所有治疗方法均促进了植入物周围的骨愈合，但 PTH+ZA 组在组织学、micro-CT 和生物力学测试中显示出比 PTH 或 ZA 单独治疗更强的效果。
结论
PTH 和 ZA 对 OVX 大鼠的植入物固定具有相加作用；提示在骨质疏松环境中，当 PTH 和 ZA 同时使用时，PTH 的合成代谢作用是有效的，不会被 ZA 削弱。
目的
研究甲状旁腺激素 1-34（PTH）和唑来膦酸（ZA）单独或联合应用对去卵巢大鼠骨质疏松环境下种植体固定的影响。
方法
12 周后，OVX 大鼠随机接受无 ZA 或 ZA（浸泡在 1mg/ml ZA 溶液中 24 小时）植入物。随后，每组一半的动物还接受 PTH（60μg/kg，每周 3 次）皮下注射 12 周。因此，有 4 组：对照组、PTH 组、ZA 组和 PTH+ZA 组。
结果
与对照组相比，所有治疗方法均促进了种植体周围的骨愈合，但 PTH+ZA 组在组织学、micro-CT 和生物力学测试中显示出比 PTH 或 ZA 单独治疗更强的效果。
结论
结果表明 PTH 和 ZA 对 OVX 大鼠种植体固定具有相加作用；提示在骨质疏松环境中，当 PTH 和 ZA 同时使用时，PTH 的合成代谢作用是有效的，不会被 ZA 削弱。
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