Hinton R J, Carlson D S
Acta Anat (Basel). 1986;125(3):145-51. doi: 10.1159/000146153.
In a study of the rat mandibular joint (MJ), Simon [Acta anat. 97: 351-360 (1977)] suggested that reduction in condylar cartilage thickness noted in animals subjected to removal or trimming of incisors resulted from the lessening of joint reaction forces produced during incision. In order to explore this question further, the microanatomy of the MJ in 47-day-old rats whose incisors had been trimmed every other day was compared to that in control animals and in a third group fed a soft diet as a control for reduced joint reaction forces. Both the incisor-clipped and soft-diet groups exhibited reduced size and density of bony trabeculae underlying the condylar cartilage and diminished staining for alcian blue. The thickness of the prechondroblastic layer of the condylar cartilage was significantly (p less than or equal to 0.01) reduced relative to controls in both experimental groups on the superior aspect of the cartilage, but was reduced in the more posterior parts of the cartilage only in the incisor-clipped group. While not denying that joint reaction forces may affect MJ response, the reduced proliferative response noted in the posterior region of the condylar cartilage in incisor-clipped animals is perhaps best explained by a decrease in the frequency and extent of protrusion of the lower jaw due to a lack of incisal preparation of food items.
在一项对大鼠下颌关节（MJ）的研究中，西蒙[《解剖学报》97: 351 - 360（1977）]提出，在接受切牙拔除或修整的动物中观察到的髁突软骨厚度减少，是由于切牙过程中产生的关节反应力减小所致。为了进一步探讨这个问题，将每隔一天修整切牙的47日龄大鼠的下颌关节微观解剖结构与对照动物以及作为关节反应力降低对照的第三组喂食软食的动物进行了比较。切牙修整组和软食组在髁突软骨下方的骨小梁大小和密度均降低，阿尔辛蓝染色减弱。在软骨上表面，两个实验组的髁突软骨前软骨层厚度相对于对照组均显著降低（p≤0.01），但仅在切牙修整组中，软骨后部区域的厚度有所降低。虽然并不否认关节反应力可能影响下颌关节的反应，但切牙修整动物髁突软骨后部区域增殖反应降低，或许最好的解释是由于缺乏对食物的切牙处理，导致下颌前伸的频率和幅度降低。
