Smith Fiona, Kotowska Anna M, Fiedler Benjamin, Cerny Edward, Cheung Karmen, Rutland Catrin S, Chowdhury Faz, Segal Joel, Rawson Frankie J, Marlow Maria
School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, United Kingdom.
School of Pharmacy, University College London, London WC1N 1AX, United Kingdom.
Mol Pharm. 2025 Jan 6;22(1):316-329. doi: 10.1021/acs.molpharmaceut.4c00942. Epub 2024 Dec 3.
Microneedles (MNs) offer the potential for discrete and painless transdermal drug delivery, yet poor insertion and dosing consistency have hindered their clinical translation. Specifically, hollow MNs are appropriate for the administration of liquid modalities, including insulin, which could prove to be beneficial for patients with type 1 diabetes mellitus. This work aimed to design and manufacture a hollow MN with an improved insertion and delivery profile suitable for insulin administration. insertion studies demonstrated that oscillation of MNs upon insertion into skin produced a favorable insertion profile, with reduced variation, compared to static MN insertion. Histological staining showed that this could be due to the repeated motion of the oscillating MN disrupting elastic fibers in the dermis. Additionally, permeation studies demonstrated that increased quantities of insulin were able to permeate the skin when oscillation was employed compared to static MN insertion. This study has shown that oscillation is a valuable tool in improving the transdermal delivery of insulin via a single hollow MN . Moving forward, studies should be completed to gain a fuller understanding of the benefits of the oscillation of MNs on transdermal drug delivery.
微针为离散且无痛的经皮给药提供了可能，但插入和给药的一致性较差阻碍了其临床应用。具体而言，中空微针适用于包括胰岛素在内的液体剂型给药，这对1型糖尿病患者可能有益。这项工作旨在设计和制造一种具有改进的插入和给药特性的中空微针，适用于胰岛素给药。插入研究表明，与静态微针插入相比，微针插入皮肤时的振荡产生了良好的插入特性，变化更小。组织学染色表明，这可能是由于振荡微针的重复运动破坏了真皮中的弹性纤维。此外，渗透研究表明，与静态微针插入相比，采用振荡时更多量的胰岛素能够渗透皮肤。这项研究表明，振荡是通过单个中空微针改善胰岛素经皮递送的一种有价值的工具。展望未来，应完成相关研究，以更全面地了解微针振荡对经皮给药的益处。
