Corrigan Kaitlyn T, Skilton Frederick J, Shea Lisa, McHugh Sean P, DeChiara James R, Porter John M, Roberts Brian W, Sarkisian Simon A
Cooper Medical School of Rowan University, Camden, NJ 08103, USA.
Department of Emergency Medicine, Cooper University Health Care, Camden, NJ 08103, USA.
Mil Med. 2025 Jun 30;190(7-8):e1493-e1499. doi: 10.1093/milmed/usae540.
Transfusion of packed red blood cells (PRBC) or low-titer group O whole blood (LTOWB) has become standard practice in trauma patients with significant blood loss. As blood ages, it undergoes metabolic and structural changes. This study aimed to test the association between age of PRBC/LTOWB and mortality among adult trauma patients.
This is a retrospective cohort study at an academic level one trauma center. Adult trauma patients who received at least one unit of PRBC or LTOWB within the first hour of arrival to the emergency department (ED) between January 2016 and December 2019 were included. The primary outcome was in-hospital mortality. Multivariable logistic regression models were used to test the associations between the mean age of PRBC and LTOWB units transfused during the initial 24 hours and in-hospital mortality.
Of 388 patients included, 362 received PRBC and 121 received LTOWB. In-hospital mortality occurred in 31% of patients. The median (interquartile range) mean age of transfused PRBC units was 21 (16-26) days and LTOWB units was 11 (9-12) days. Neither age of PRBC nor LTOWB were found to be associated with in-hospital mortality: PRBC adjusted odds ratio (aOR) = 0.99 (95% CI 0.95 to 1.03) and LTOWB aOR = 1.12 (95% CI 0.88 to 1.41).
The mean age of LTOWB or PRBC units transfused during the first 24 hours after presenting to the ED for a traumatic injury was not found to be associated with in-hospital mortality.
输注浓缩红细胞（PRBC）或低滴度O型全血（LTOWB）已成为大量失血创伤患者的标准治疗方法。随着血液老化，其会发生代谢和结构变化。本研究旨在测试PRBC/LTOWB的储存时间与成年创伤患者死亡率之间的关联。
这是一项在一级学术创伤中心进行的回顾性队列研究。纳入2016年1月至2019年12月期间在急诊科（ED）就诊的前1小时内接受至少1单位PRBC或LTOWB的成年创伤患者。主要结局是住院死亡率。使用多变量逻辑回归模型来测试在最初24小时内输注的PRBC和LTOWB单位的平均储存时间与住院死亡率之间的关联。
在纳入的388例患者中，362例接受了PRBC，121例接受了LTOWB。31%的患者发生了住院死亡。输注的PRBC单位的中位（四分位间距）平均储存时间为21（16 - 26）天，LTOWB单位为11（9 - 12）天。未发现PRBC或LTOWB的储存时间与住院死亡率相关：PRBC调整优势比（aOR）= 0.99（95%CI 0.95至1.03），LTOWB的aOR = 1.12（95%CI 0.88至1.41）。
对于创伤性损伤患者，在到达ED后的最初24小时内输注的LTOWB或PRBC单位的平均储存时间与住院死亡率无关。
