Yin Yijia, Shuai Fangyuan, Liu Xian, Zhao Yuxi, Han Xianglong, Zhao Hang
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, PR China.
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, PR China.
Biomaterials. 2025 May;316:122975. doi: 10.1016/j.biomaterials.2024.122975. Epub 2024 Nov 29.
Tooth extraction is the most commonly performed oral surgical procedure, with a wide range of clinical indications. The oral cavity is a complex microenvironment, influenced by oral movements, salivary flow, and bacterial biofilms. These factors can contribute to delayed socket healing and the onset of post-extraction complications, which can burden patients' esthetic and functional rehabilitation. Achieving effective extraction socket healing requires a multidisciplinary approach. Recent advancements in materials science and bioengineering have paved the way for developing novel strategies. This review outlines the fundamental healing processes and cellular-molecular interactions involved in the healing of extraction sockets. It then delves into the current landscape of biomaterials for socket healing, highlighting emerging strategies and potential targets that could transform the treatment paradigm. Building upon this foundation, this review also presents future directions and identifies challenges associated with the clinical application of biomaterials for extraction socket healing.
拔牙是最常施行的口腔外科手术，具有广泛的临床适应症。口腔是一个复杂的微环境，受口腔运动、唾液流动和细菌生物膜的影响。这些因素可导致拔牙创愈合延迟和拔牙后并发症的发生，这会给患者的美观和功能康复带来负担。实现有效的拔牙创愈合需要多学科方法。材料科学和生物工程的最新进展为开发新策略铺平了道路。本综述概述了拔牙创愈合所涉及的基本愈合过程以及细胞 - 分子相互作用。然后深入探讨了用于拔牙创愈合的生物材料的当前状况，强调了可能改变治疗模式的新兴策略和潜在靶点。在此基础上，本综述还提出了未来方向，并确定了生物材料在拔牙创愈合临床应用中相关的挑战。
