Yu Wenqing, Hu Liwei, Wei Yige, Xue Chengyu, Liu Yunfei, Xie Huixu
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China.
Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing 401147, PR China.
Biomater Adv. 2025 Aug;173:214280. doi: 10.1016/j.bioadv.2025.214280. Epub 2025 Mar 9.
Tooth extraction is a common oral surgical procedure that often leads to delayed alveolar socket healing due to the complexity of the oral microenvironment, which can hinder the patient's aesthetic and functional recovery. Effective alveolar socket healing requires a multidisciplinary approach. Recent advancements in materials science and bioengineering have facilitated the development of innovative strategies, with hydrogels emerging as ideal restorative materials for alveolar socket repair due to their superior properties. This review provides an overview of recent advances in hydrogels for alveolar socket healing, focusing on their classification, physical properties (e.g., mechanical strength, swelling behavior, degradation rate, and injectability), biological functions, and applications in relevant animal models. Specifically, the bone-regenerative and antimicrobial properties of hydrogels are highlighted. Furthermore, this review identifies future directions and addresses challenges associated with the clinical application of hydrogels in extraction socket healing.
拔牙是一种常见的口腔外科手术，由于口腔微环境的复杂性，常常导致牙槽窝愈合延迟，这可能会阻碍患者的美观和功能恢复。有效的牙槽窝愈合需要多学科方法。材料科学和生物工程的最新进展推动了创新策略的发展，水凝胶因其卓越的性能而成为牙槽窝修复的理想修复材料。本文综述了用于牙槽窝愈合的水凝胶的最新进展，重点介绍了它们的分类、物理性质（如机械强度、膨胀行为、降解速率和可注射性）、生物学功能以及在相关动物模型中的应用。具体而言，突出了水凝胶的骨再生和抗菌特性。此外，本文还确定了未来的方向，并探讨了水凝胶在拔牙窝愈合临床应用中面临的挑战。
