从细胞核到细胞外的PTEN：在肿瘤抑制和免疫调节中的多重作用。
From nuclear to extracellular PTEN: Multiple roles in tumor suppression and immune modulation.
作者信息
Lu Dan, Yin Yuxin
机构信息
Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
出版信息
Dev Cell. 2024 Dec 2;59(23):3059-3060. doi: 10.1016/j.devcel.2024.09.019.
In this issue of Developmental Cell, Zhang et al. report that secreted PTEN reprograms immunosuppressive tumor-associated macrophages into an inflammatory phenotype by binding to PLXDC2, which enhances antitumor immunity. This Preview discusses diverse functions of PTEN in the nucleus, cytoplasm, and extracellular matrix, highlighting its multifaceted roles in cancer.
在本期《发育细胞》杂志中，张等人报道，分泌型PTEN通过与PLXDC2结合，将免疫抑制性肿瘤相关巨噬细胞重编程为炎症表型，从而增强抗肿瘤免疫力。本综述讨论了PTEN在细胞核、细胞质和细胞外基质中的多种功能，突出了其在癌症中的多方面作用。
Zotero 插件