PTEN 抑瘤剂？进出细胞以实现肿瘤抑制。
Pills of PTEN? In and out for tumor suppression.
机构信息
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cell Res. 2013 Oct;23(10):1155-6. doi: 10.1038/cr.2013.103. Epub 2013 Aug 6.
Abstract
The tumor-suppressive activity of PTEN has always been attributed to its endogenous intracellular function. Recently two different groups have demonstrated that PTEN is secreted/exported into the extracellular environment for uptake by recipient cells, and functions as a tumor suppressor in a cell non-autonomous manner.
摘要
PTEN 的肿瘤抑制活性一直归因于其内在的细胞内功能。最近，两个不同的研究小组证明了 PTEN 可以被分泌/输出到细胞外环境，被受体细胞摄取，并以非自主细胞的方式发挥肿瘤抑制作用。
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