Leyssac P P, Jensen P K, Holstein-Rathlou N H
Acta Physiol Scand. 1986 Mar;126(3):341-8. doi: 10.1111/j.1748-1716.1986.tb07825.x.
Proximal tubular compliance (C) was measured in free flow microperfusion experiments from the initial slope of the increase in proximal luminal pressure divided by the step input of volume flow delivered from a microperfusion pipette inserted in a downstream proximal convolution. Five groups of rats were studied: Munich Wistar (WU, n = 11) and Sprague-Dawley rats (SPRD, n = 6) anaesthetized with inactin; and SPRD (n = 11), Wistar Kyoto (WKY, n = 9), and spontaneously hypertensive rats (SHR, n = 11) anaesthetized with halothane. In the inactin groups, C was: 0.309 +/- 0.161 and 0.266 +/- 0.136 nl mm Hg-1, respectively. In the halothane groups, C was: 0.125 +/- 0.023, 0.125 +/- 0.029, and 0.119 +/- 0.0127 nl mm Hg-1, respectively. The means in the inactin groups were significantly higher than those from the halothane groups (P less than 0.001). It is concluded that the choice of anaesthetics has a profound influence on the proximal tubular compliance in the rat, and that the compliance of SHR is equal to that of normotensive rats.
在自由流动微灌注实验中，通过将插入下游近端曲段的微灌注移液器输送的体积流量的阶跃输入除以近端管腔压力升高的初始斜率，来测量近端肾小管顺应性（C）。研究了五组大鼠：用安乃近麻醉的慕尼黑Wistar大鼠（WU，n = 11）和Sprague-Dawley大鼠（SPRD，n = 6）；以及用氟烷麻醉的SPRD大鼠（n = 11）、Wistar Kyoto大鼠（WKY，n = 9）和自发性高血压大鼠（SHR，n = 11）。在安乃近组中，C分别为0.309±0.161和0.266±0.136 nl·mmHg⁻¹。在氟烷组中，C分别为0.125±0.023、0.125±0.029和0.119±0.0127 nl·mmHg⁻¹。安乃近组的平均值显著高于氟烷组（P＜0.001）。得出的结论是，麻醉剂的选择对大鼠近端肾小管顺应性有深远影响，并且SHR的顺应性与正常血压大鼠的顺应性相等。
