Nielsen Valdemar Wendelboe, Thomsen Simon Francis, Naik Haley B
Department of Dermato-Venereology & Wound Healing Centre, Copenhagen University Hospital - Bispebjerg & Frederiksberg, Copenhagen, Denmark.
Department of Dermato-Venereology & Wound Healing Centre, Copenhagen University Hospital - Bispebjerg & Frederiksberg, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
J Am Acad Dermatol. 2024 Dec;91(6S):S17-S21. doi: 10.1016/j.jaad.2024.07.1524.
While genetic predisposition and immune dysregulation are recognized as key contributors to the development of hidradenitis suppurativa, accumulating research points to the influence of extrinsic factors in the pathogenesis of this condition. This review explores the roles of mechanical stress, altered skin and gut microbiome, tobacco smoking, diet, and paradoxical drug reactions as drivers of hidradenitis suppurativa onset and progression. A holistic management approach addressing these factors may be encouraged to improve disease outcomes. Further research is needed to fully determine the causal role of these extrinsic factors and their impact on treatment strategies.
虽然遗传易感性和免疫失调被认为是化脓性汗腺炎发病的关键因素，但越来越多的研究指出外在因素在这种疾病发病机制中的影响。本综述探讨了机械应力、皮肤和肠道微生物群改变、吸烟、饮食以及反常药物反应在化脓性汗腺炎发病和进展中的驱动作用。可能会鼓励采用一种综合管理方法来应对这些因素，以改善疾病预后。需要进一步研究来全面确定这些外在因素的因果作用及其对治疗策略的影响。
