皮肤微生物群与化脓性汗腺炎之间的因果关系：一项两样本孟德尔随机化研究

Causal relationship between skin microbiota and Hidradenitis suppurativa: a two-sample Mendelian randomization study.

作者信息

Guo Siqing, Li Peihong, Lu Jingen, Zhou Pengfei, Sun Boyun, Wang Jiawen

机构信息

Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

出版信息

Arch Dermatol Res. 2025 Jan 13;317(1):238. doi: 10.1007/s00403-024-03787-3.

DOI:10.1007/s00403-024-03787-3

PMID:39804488

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11729072/

Abstract

BACKGROUND

Data from observational and clinical studies indicate an association between skin microbiota and hidradenitis suppurativa (HS). However, the causal relationship between skin microbiota and HS remains to be elucidated.

METHODS

We obtained data on skin microbiota and HS from summary statistics of genome-wide association studies and applied Mendelian randomization (MR) statistical methods to assess causality. Specifically, we employed both full MR and inverse MR methods, utilizing five statistical approaches, including inverse variance weighting, to evaluate causality. Furthermore, sensitivity analyses were conducted to validate the MR findings.

RESULTS

Inverse variance weighted analysis revealed that the order Burkholderiales (OR = 0.922, 95% CI 0.855-0.994, P = 0.033), the genus Enhydrobacter (OR = 0.897, 95% CI 0.815-0.986, P = 0.025), ASV037 (OR = 0.926, 95% CI 0.863-0.995, P = 0.036), and ASV016 (OR = 0.932, 95% CI 0.870-0.998, P = 0.043) exhibited a protective effect against HS. Conversely, ASV022 (OR = 1.098, 95% CI 1.027-1.175, P = 0.007) was identified as a risk factor.

CONCLUSION

Our analysis suggests a possible causal relationship between specific skin microbiota and HS. These findings shed light on the potential pathogenesis and therapeutic interventions.

摘要

背景

观察性研究和临床研究的数据表明皮肤微生物群与化脓性汗腺炎（HS）之间存在关联。然而，皮肤微生物群与HS之间的因果关系仍有待阐明。

方法

我们从全基因组关联研究的汇总统计数据中获取了皮肤微生物群和HS的数据，并应用孟德尔随机化（MR）统计方法来评估因果关系。具体而言，我们采用了全MR和逆MR方法，利用包括逆方差加权在内的五种统计方法来评估因果关系。此外，还进行了敏感性分析以验证MR结果。

结果

逆方差加权分析显示，伯克霍尔德氏菌目（OR = 0.922，95%CI 0.855 - 0.994，P = 0.033）、水生杆菌属（OR = 0.897，95%CI 0.815 - 0.986，P = 0.025）、ASV037（OR = 0.926，95%CI 0.863 - 0.995，P = 0.036）和ASV016（OR = 0.932，95%CI 0.870 - 0.998，P = 0.043）对HS具有保护作用。相反，ASV022（OR = 1.098，95%CI 1.027 - 1.175，P = 0.007）被确定为一个风险因素。