Warrington Lorraine, Absolom Kate, Baxter Paul, Bojke Chris, Clarke Gemma, Crossfield Samantha, Johnston Colin, Martin Adam, McInerney Ciaran D, Saalmink Gwen, Siciliano Michele, Stamp Elizabeth, Velikova Galina, Wilkinson David, Woroncow Barbara, Wright Penny, Zucker Kieran, Hall Geoff, Glaser Adam
Patient Centred Outcomes Research, Leeds Institute of Medical Research at St James's, University of Leeds, Level 6 Bexley Wing, Leeds, UK.
Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK.
J Cancer Surviv. 2024 Dec 3. doi: 10.1007/s11764-024-01708-x.
Assessing the long-term impact of cancer on people's lives is challenging due to confounding issues such as aging and comorbidities. We aimed to investigate this impact by comparing the outcomes of cancer survivors with a matched control cohort.
This was a cross-sectional survey of breast, colorectal and ovarian cancer survivors approximately 5 years post-diagnosis and a cohort of age, sex and social deprivation-matched controls who had never had a cancer diagnosis. Eligible participants were invited by post to complete a survey assessing quality of life (QoL), health, identity, healthcare usage and finances.
A total of 2075 out of 5734 (36.2%) eligible participants participated (852 cancer survivors and 1223 matched controls). Cancer survivors had poorer QoL than matched controls as assessed by the Quality of Life of Adult Cancer Survivors (QLACS) summary score (p = 0.007); however, the effect size was modest (ω = 0.121). The cancer survivors also reported worse outcomes across some individual domains of QoL and health, but not others, and differences were small. There were few differences between cohorts across healthcare usage and finances.
Five years or more after diagnosis, the QoL, healthcare usage and finances of breast, colorectal and ovarian cancer survivors were generally similar to that of age, sex and IMD-matched controls.
This finding has important implications for people affected by cancer and those providing care who would benefit from greater information on outcomes and functioning beyond treatment. Despite this reassuring finding, it is important to note that there were some differences, on both physical and psychosocial issues, mandating the need for specialist service provision.
由于衰老和合并症等混杂问题，评估癌症对人们生活的长期影响具有挑战性。我们旨在通过比较癌症幸存者与匹配的对照队列的结果来研究这种影响。
这是一项横断面调查，对象为乳腺癌、结直肠癌和卵巢癌幸存者，诊断后约5年，以及一组年龄、性别和社会剥夺情况相匹配且从未被诊断患有癌症的对照人群。通过邮寄邀请符合条件的参与者完成一项调查，评估生活质量（QoL）、健康状况、身份认同、医疗保健使用情况和财务状况。
5734名符合条件的参与者中，共有2075人（36.2%）参与（852名癌症幸存者和1223名匹配对照）。根据成人癌症幸存者生活质量（QLACS）综合评分，癌症幸存者的生活质量低于匹配对照（p = 0.007）；然而，效应大小适中（ω = 0.121）。癌症幸存者在生活质量和健康的一些个别领域也报告了更差的结果，但其他领域并非如此，差异较小。不同队列在医疗保健使用和财务方面几乎没有差异。
诊断后五年或更长时间，乳腺癌、结直肠癌和卵巢癌幸存者的生活质量、医疗保健使用情况和财务状况通常与年龄、性别和IMD匹配的对照人群相似。
这一发现对受癌症影响的人和提供护理的人具有重要意义，他们将受益于更多关于治疗后结果和功能的信息。尽管这一发现令人安心，但需要注意的是，在身体和心理社会问题上存在一些差异，这就需要提供专科服务。
