更好的心脏代谢/炎症特征与2型糖尿病患者锁骨上脂肪组织活性的差异有关。
Better cardiometabolic/inflammatory profile is associated with differences in the supraclavicular adipose tissue activity of individuals with T2DM.
作者信息
Bonfante Ivan Luiz Padilha, Segantim Higor da Silva, Mendonça Kauê Neto Soares, de Oliveira Murilo Augusto Belmiro, Monfort-Pires Milena, Duft Renata Garbellini, da Silva Mateus Keryma Chaves, Chacon-Mikahil Mara Patricia Traina, Ramos Celso Darío, Velloso Licio Augusto, Cavaglieri Cláudia Regina
机构信息
Laboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, Brazil.
Postdoctoral Researcher Program (PPPD), University of Campinas, Campinas, Brazil.
出版信息
Endocrine. 2025 Mar;87(3):1011-1021. doi: 10.1007/s12020-024-04122-6. Epub 2024 Dec 3.
PURPOSE
Brown adipose tissue (BAT), located in the supraclavicular region, has been associated with a better cardiometabolic profile and reduced risk of developing non-communicable chronic diseases (NCD), in addition to being associated with a healthier phenotype in obesity. However, it is unknown whether greater supraclavicular adipose tissue activity could be associated with a healthier metabolic profile in people already diagnosed with type 2 diabetes (T2DM). Thus, the present work evaluated if supraclavicular adipose tissue activity is associated with metabolic and molecular markers in individuals with T2DM.
METHODS
Based on a cluster study, individuals with T2DM were divided into groups according to high or low-standard uptake value (SUV) evaluated in the supraclavicular adipose tissue area by [18F]-fluorodeoxyglucose and positron emission tomography-computed tomography (F-FDG-PET/CT) after mild cold exposure). Functional, biochemical, inflammatory, and molecular markers were measured.
RESULTS
When we evaluated the whole sample, women showed higher SUV, which favored a difference between groups in sex-related markers. On the other hand, volunteers in the high-SUV group showed lower BMI, monocytes count, triglycerides/glucose index (TYG-index) and z score of metabolic syndrome (MS) values, as well as lower triglycerides, and VLDL concentrations. Moreover, they also had enhanced expression of thermogenic genes in subcutaneous fat. When analyzing only women, the differences in markers associated with sex disappear, and a lower count of leukocytes, platelets, along with lower TYG-index, z score of MS values, and triglycerides, VLDL, LDL, and TNFα concentrations were observed in women with the high SUV. In addition, higher expression of thermogenic genes and BECN1 were detected.
CONCLUSION
Higher supraclavicular adipose tissue SUV in individuals with T2DM is associated with a better cardiometabolic/inflammatory profile and expression of thermogenic genes.
CLINICAL TRIAL REGISTRATION
UTN: U1111-1202-1476 - 08/20/2020.
目的
位于锁骨上区域的棕色脂肪组织（BAT），除了与肥胖人群中更健康的表型相关外，还与更好的心脏代谢状况以及降低患非传染性慢性病（NCD）的风险有关。然而，尚不清楚锁骨上脂肪组织活性增强是否与已确诊2型糖尿病（T2DM）的人群更健康的代谢状况相关。因此，本研究评估了锁骨上脂肪组织活性是否与T2DM患者的代谢和分子标志物相关。
方法
基于一项聚类研究，在轻度冷暴露后，通过[18F] - 氟脱氧葡萄糖和正电子发射断层扫描 - 计算机断层扫描（F - FDG - PET/CT）评估锁骨上脂肪组织区域的标准化摄取值（SUV）高低，将T2DM患者分为两组。测量功能、生化、炎症和分子标志物。
结果
当我们评估整个样本时，女性的SUV较高，这使得与性别相关的标志物在组间存在差异。另一方面，高SUV组的志愿者BMI、单核细胞计数、甘油三酯/葡萄糖指数（TYG指数）和代谢综合征（MS）值的z评分较低，同时甘油三酯和极低密度脂蛋白（VLDL）浓度也较低。此外，他们皮下脂肪中产热基因的表达增强。仅分析女性时，与性别相关的标志物差异消失，高SUV女性的白细胞、血小板计数较低，同时TYG指数、MS值的z评分以及甘油三酯、VLDL、低密度脂蛋白（LDL）和肿瘤坏死因子α（TNFα）浓度也较低。此外，还检测到产热基因和自噬相关基因1（BECN1）的表达较高。
结论
T2DM患者较高的锁骨上脂肪组织SUV与更好的心脏代谢/炎症状况以及产热基因的表达相关。
临床试验注册
UTN：U1111 - 1202 - 1476 - 2020年8月20日。
Zotero 插件