Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA; Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, Medical Research Council Metabolic Diseases Unit, University of Cambridge, Cambridge, UK; Department of Nutritional Sciences and Dietetics, Harokopio University of Athens, Kallithea, Greece.
Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA.
Cell Rep Med. 2024 Jan 16;5(1):101370. doi: 10.1016/j.xcrm.2023.101370.
Although a high amount of brown adipose tissue (BAT) is associated with low plasma triglyceride concentration, the mechanism responsible for this relationship in people is not clear. Here, we evaluate the interrelationships among BAT, very-low-density lipoprotein triglyceride (VLDL-TG), and free fatty acid (FFA) plasma kinetics during thermoneutrality in women with overweight/obesity who had a low (<20 mL) or high (≥20 mL) volume of cold-activated BAT (assessed by using positron emission tomography in conjunction with 2-deoxy-2-[F]-fluoro-glucose). We find that plasma TG and FFA concentrations are lower and VLDL-TG and FFA plasma clearance rates are faster in women with high BAT than low BAT volume, whereas VLDL-TG and FFA appearance rates in plasma are not different between the two groups. These findings demonstrate that women with high BAT volume have lower plasma TG and FFA concentrations than women with low BAT volumes because of increased VLDL-TG and FFA clearance rates. This study was registered at ClinicalTrials.gov (NCT02786251).
虽然大量棕色脂肪组织（BAT）与血浆甘油三酯浓度低有关，但这一关系在人群中的机制尚不清楚。在这里，我们评估了超重/肥胖女性在体温中性条件下 BAT、极低密度脂蛋白甘油三酯（VLDL-TG）和游离脂肪酸（FFA）之间的相互关系，这些女性的 BAT 体积较低（<20 mL）或较高（≥20 mL）（通过正电子发射断层扫描与 2-脱氧-2-[F]-氟葡萄糖联合评估）。我们发现，BAT 体积较高的女性的血浆 TG 和 FFA 浓度较低，VLDL-TG 和 FFA 血浆清除率较快，而两组之间的 VLDL-TG 和 FFA 血浆出现率没有差异。这些发现表明，BAT 体积较高的女性的血浆 TG 和 FFA 浓度较低，是因为 VLDL-TG 和 FFA 清除率增加。这项研究在 ClinicalTrials.gov 注册（NCT02786251）。
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