Gu Hezirui, Xie Wenqing, Li Hengzhen, Liu Shuguang, Li Yusheng
Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Animal Model Exp Med. 2025 Jan;8(1):92-101. doi: 10.1002/ame2.12516. Epub 2024 Dec 3.
Frozen shoulder (FS), also known as adhesive capsulitis, is a condition that causes contraction and stiffness of the shoulder joint capsule. The main symptoms are persistent shoulder pain and a limited range of motion in all directions. These symptoms and poor prognosis affect people's physical health and quality of life. Currently, the specific mechanisms of FS remain unclear, and there is variability in treatment methods and their efficacy. Additionally, the early symptoms of FS are difficult to distinguish from those of other shoulder diseases, complicating early diagnosis and treatment. Therefore, it is necessary to develop and utilize animal models to understand the pathogenesis of FS and to explore treatment strategies, providing insights into the prevention and treatment of human FS. This paper reviews the rat models available for FS research, including external immobilization models, surgical internal immobilization models, injection modeling models, and endocrine modeling models. It introduces the basic procedures for these models and compares and analyzes the advantages, disadvantages, and applicability of each modeling method. Finally, our paper summarizes the common methods for evaluating FS rat models.
冻结肩（FS），也称为粘连性关节囊炎，是一种导致肩关节囊收缩和僵硬的病症。主要症状为肩部持续疼痛和各个方向活动范围受限。这些症状以及预后不佳会影响人们的身体健康和生活质量。目前，冻结肩的具体发病机制仍不清楚，治疗方法及其疗效存在差异。此外，冻结肩的早期症状难以与其他肩部疾病的症状区分开来，使得早期诊断和治疗变得复杂。因此，有必要开发和利用动物模型来了解冻结肩的发病机制并探索治疗策略，为人类冻结肩的预防和治疗提供见解。本文综述了可用于冻结肩研究的大鼠模型，包括外固定模型、手术内固定模型、注射建模模型和内分泌建模模型。介绍了这些模型的基本操作步骤，并对每种建模方法的优缺点及适用性进行了比较和分析。最后，本文总结了评估冻结肩大鼠模型的常用方法。
