Svensson Nikoline, Henriksen Magnus Grønbæk, Møller Ann Merete
Department of Anaesthesiology, Herlev and Gentofte Hospital, Herlev, Denmark.
Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
Acta Anaesthesiol Scand. 2025 Jan;69(1):e14556. doi: 10.1111/aas.14556.
Opioid-dependent patients with chronic pain conditions present a significant challenge for anesthesiologists when managing acute postsurgical pain. Opioid-dependent patients can experience tolerance, physical dependence, and hyperalgesia. These patients have an increased risk of poorly managed acute postoperative pain, which can ultimately lead to suffering and potentially an overall increase in length of hospitalization and healthcare cost. However, this is an under-researched field. This scoping review aims to investigate effective strategies in managing postoperative pain in patients with preexisting opioid dependence.
A scoping review will be conducted on postoperative pain management in patients with preexisting opioid dependence. This review will be prepared according to the JBI methodology for scoping reviews and to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR). We will conduct a comprehensive search across multiple databases. Backward citation searching of the final included articles will also be conducted. Data extraction will include trial and participant characteristics, intervention details, and reported outcomes.
In the final review the results will be presented as a descriptive summary with supplementary tables, figures, and graphs where applicable.
The planned scoping review will map out the current evidence about effective strategies to manage postoperative pain in patients with preexisting opioid dependence. We will aim to identify research gaps that can be used as support in the development of further research.
对于麻醉医生而言，患有慢性疼痛疾病的阿片类药物依赖患者在处理术后急性疼痛时是一项重大挑战。阿片类药物依赖患者会出现耐受性、身体依赖性和痛觉过敏。这些患者术后急性疼痛管理不善的风险增加，这最终可能导致痛苦，并可能使住院时间和医疗费用总体增加。然而，这是一个研究不足的领域。本综述旨在探讨对已有阿片类药物依赖的患者进行术后疼痛管理的有效策略。
将对已有阿片类药物依赖的患者的术后疼痛管理进行综述。本综述将根据循证卫生保健国际协作组织（JBI）的综述方法以及系统评价与Meta分析优先报告条目扩展版（PRISMA-ScR）进行撰写。我们将在多个数据库中进行全面检索。还将对最终纳入的文章进行反向引文检索。数据提取将包括试验和参与者特征、干预细节以及报告的结果。
在最终综述中，结果将以描述性总结的形式呈现，并在适用时辅以表格、图表和图形。
计划进行的综述将梳理出有关对已有阿片类药物依赖的患者进行术后疼痛管理的有效策略的现有证据。我们旨在找出可用于支持进一步研究的研究空白。
