新冠疫情限制措施对未治疗精神病持续时间的异常影响。
The anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis.
作者信息
Nicholls-Mindlin Jessica, Hazan Hadar, Zhou Bin, Li Fangyong, Ferrara Maria, Levine Nina, Riley Sarah, Karmani Sneha, Mathis Walter S, Keshavan Matcheri S, Srihari Vinod H
机构信息
Medical Sciences Division, University of Oxford, Oxford, UK; and Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Program for Specialized Treatment Early in Psychosis (STEP), Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
BJPsych Open. 2024 Dec 4;10(6):e216. doi: 10.1192/bjo.2024.813.
We investigated the impact of COVID-19 restrictions on the duration of untreated psychosis (DUP). First-episode psychosis admissions ( = 101) to the STEP Clinic in Connecticut showed DUP reduction ( = 0.0015) during the pandemic, with the median reducing from 208 days pre-pandemic to 56 days in the early pandemic period, and subsequently increasing to 154 days ( = 0.0281). Time from psychosis onset to antipsychotic prescription decreased significantly in the pandemic ( = 0.0183), with the median falling from 117 to 35 days. This cohort study demonstrates an association between greater pandemic restrictions and marked DUP reduction, and provides insights for future early detection efforts.
我们调查了新冠疫情限制措施对未治疗精神病持续时间（DUP）的影响。康涅狄格州STEP诊所的首发精神病住院患者（n = 101）显示，在疫情期间DUP有所减少（p = 0.0015），中位数从疫情前的208天降至疫情早期的56天，随后又增至154天（p = 0.0281）。从精神病发作到开始使用抗精神病药物治疗的时间在疫情期间显著缩短（p = 0.0183），中位数从117天降至35天。这项队列研究表明，更严格的疫情限制措施与DUP显著减少之间存在关联，并为未来的早期检测工作提供了见解。
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