Qin Yujie, Deng Hongyang, Lu Mengnan, Liu Lujie, Li Meng, Zhou Jing, Xiao Yanfeng
Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Pediatrics, Xijing Hospital, Xi'an, China.
Clin Endocrinol (Oxf). 2025 Apr;102(4):443-452. doi: 10.1111/cen.15173. Epub 2024 Dec 3.
Diet is an important factor influencing central precocious puberty (CPP). This study aimed to investigate the relationship among diet quality, pro-inflammatory diets, and CPP in Chinese girls.
DESIGN, PATIENTS AND MEASUREMENTS: This case-control study enroled 112 Chinese girls with CPP and 131 healthy controls. Children's dietary intake was assessed using a validated food frequency questionnaire, anthropometric and sociodemographic data were collected and serum interleukin-6 levels were measured. We calculated the Children's Dietary Inflammatory Index (C-DII), Chinese Children's Dietary Index (CCDI), Dietary Approaches to Stop Hypertension (DASH) score, and the adjusted Dietary Approaches to Stop Hypertension (aDASH) score. The association between diet and the risk of CPP was analysed using logistic regression models.
After adjustment, higher C-DII scores were associated with an increased risk of CPP (P for trend = 0.034), and aDASH scores were significantly negatively associated with the risk of CPP (P for trend = 0.048). Serum IL-6 levels were significantly higher in the case group than in the control group and were positively correlated with the risk of CPP (P for trend = 0.006).
High-quality dietary patterns and an anti-inflammatory diet may contribute to the prevention of CPP in Chinese girls.
饮食是影响中枢性性早熟（CPP）的一个重要因素。本研究旨在探讨中国女孩饮食质量、促炎饮食与CPP之间的关系。
设计、研究对象与测量方法：本病例对照研究纳入了112名患有CPP的中国女孩和131名健康对照。使用经过验证的食物频率问卷评估儿童的饮食摄入量，收集人体测量和社会人口学数据，并测量血清白细胞介素-6水平。我们计算了儿童饮食炎症指数（C-DII）、中国儿童饮食指数（CCDI）、终止高血压膳食方法（DASH）评分以及调整后的终止高血压膳食方法（aDASH）评分。使用逻辑回归模型分析饮食与CPP风险之间的关联。
调整后，较高的C-DII评分与CPP风险增加相关（趋势P值=0.034），aDASH评分与CPP风险显著负相关（趋势P值=0.048）。病例组血清IL-6水平显著高于对照组，且与CPP风险呈正相关（趋势P值=0.006）。
高质量的饮食模式和抗炎饮食可能有助于预防中国女孩的CPP。
