帕金森病患者行走时震颤的神经生理特征
Neurophysiological Features of Tremor during Walking in Parkinson's Disease.
作者信息
Costanzo Matteo, Marchet Francesco, Leodori Giorgio, Cutrona Carolina, De Bartolo Maria Ilenia, Vivacqua Giorgio, Conte Antonella, Fabbrini Giovanni, Berardelli Alfredo, Belvisi Daniele
机构信息
Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Department of Neuroscience, Istituto Superiore di Sanità, Rome, Italy.
出版信息
Mov Disord Clin Pract. 2025 Feb;12(2):226-230. doi: 10.1002/mdc3.14293. Epub 2024 Dec 3.
BACKGROUND
In Parkinson's Disease (PD), upper limb tremor during walking (TW) is observed and clinical observations suggest it may represent a variant of rest tremor. However, its neurophysiological characteristics remain unexplored.
OBJECTIVES
This study compared the neurophysiological features of TW with other PD tremors and tested whether TW arises from reduced ipsilateral arm swing.
METHODS
Inertial measurement units were used to measure frequency and amplitude of tremors and arm swing during walking in 25 PD patients.
RESULTS
TW shared a similar frequency with rest and re-emergent tremor (RET) but showed significantly greater amplitude. A positive correlation was observed between the amplitude and frequency of TW with those of rest and RET on the same side. TW distribution was unrelated to reduced arm swing during walking, suggesting TW is not due to decreased ipsilateral arm movement.
CONCLUSIONS
These findings suggest that walking may act as a provocation maneuver, triggering rest tremor.
背景
在帕金森病（PD）中，观察到行走时上肢震颤（TW），临床观察表明它可能代表静止性震颤的一种变体。然而，其神经生理学特征仍未得到探索。
目的
本研究比较了TW与其他PD震颤的神经生理学特征，并测试TW是否源于同侧手臂摆动减少。
方法
使用惯性测量单元测量25例PD患者行走时震颤的频率和幅度以及手臂摆动情况。
结果
TW与静止性震颤和再发性震颤（RET）频率相似，但幅度明显更大。观察到TW的幅度和频率与同侧静止性震颤和RET的幅度和频率呈正相关。TW的分布与行走时手臂摆动减少无关，表明TW并非由于同侧手臂运动减少所致。
结论
这些发现表明行走可能起到激发作用，触发静止性震颤。
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