Costanzo Matteo, Cutrona Carolina, Leodori Giorgio, De Bartolo Maria Ilenia, Fabbrini Andrea, Vivacqua Giorgio, Conte Antonella, Fabbrini Giovanni, Berardelli Alfredo, Belvisi Daniele
IRCCS Neuromed Pozzilli Italy.
Department of Human Neurosciences Sapienza University of Rome Rome Italy.
Mov Disord Clin Pract. 2023 Jun 22;10(8):1198-1202. doi: 10.1002/mdc3.13814. eCollection 2023 Aug.
Distal upper limb tremor during walking (TW) is frequently observed in Parkinson's disease (PD) but its clinical features are unknown.
To characterize the occurrence and the clinical features of TW in comparison to the other types of tremors in PD.
Fifty-one PD patients with rest tremor were evaluated off- and on-treatment. Occurrence, body distribution, severity and latency of TW and of other tremor types were assessed.
TW was present in 78% of the PD patients examined. TW body distribution and severity were similar to those of rest and re-emergent tremor but different from the postural tremor presented by the same patients. TW latency, observed in 85% of patients, was on average 5.8 s. Dopaminergic treatment significantly improved TW, rest, and re-emergent tremor severity but left TW latency unaffected.
TW is a frequent motor sign in PD and is likely a clinical variant of rest tremor.
帕金森病（PD）患者在行走时经常出现上肢远端震颤（TW），但其临床特征尚不清楚。
与PD的其他类型震颤相比，对TW的发生情况和临床特征进行描述。
对51例有静止性震颤的PD患者在治疗前和治疗期间进行评估。评估TW及其他震颤类型的发生情况、身体分布、严重程度和潜伏期。
在接受检查的PD患者中，78%存在TW。TW的身体分布和严重程度与静止性震颤和再发性震颤相似，但与同一患者出现的姿势性震颤不同。85%的患者观察到TW潜伏期，平均为5.8秒。多巴胺能治疗显著改善了TW、静止性震颤和再发性震颤的严重程度，但未影响TW潜伏期。
TW是PD中常见的运动体征，可能是静止性震颤的临床变异型。
