Imboumy-Limoukou Roméo Karl, Biteghe-Bi-Essone Jean Claude, Oyegue-Liabagui Sandrine Lydie, Ekogha-Ovono Jean Jordan, Nascimento D'Alva Noronha Ingrid, Ontoua Steede Seinnat, Ntigui Cherone Nancy Mbani Mpega, Kouna Lady Charlène, Lekana-Douki Jean Bernard
Unit of Evolution, Epidemiology and Parasitic Resistances (UNEEREP), Franceville International Medical Research Center (CIRMF), Franceville, Gabon.
Masuku University of Science and Technology, Molecular and Cell Biology Laboratory (LABMC), Franceville, Gabon.
Niger Postgrad Med J. 2024 Oct 1;31(4):318-324. doi: 10.4103/npmj.npmj_200_24. Epub 2024 Dec 4.
Malaria remains the deadliest parasitic disease and continues to cause more than half a million deaths across the world each year, mainly victims are sub-Saharan children. Malaria is a common reason for paediatric hospitalisation.
The objective was to characterise malaria and describe the evolution after treatment in the paediatric department of the University Hospital Centre Amissa Bongo de Franceville.
This was a cross-sectional study conducted from 1 February 2023 to 15 May 2023. A clinical and biological diagnosis was made in febrile children aged from 6 months to 15 years.
A total of 306 patients were included. The mean age was 50.4 ± 44.3 months, 94.3% had consulted within ≥48 h and self-medication was practiced by 83.3%. The prevalence of malaria was 17.3%. Fever ˃39°8C (adjusted odds ratios [aOR] = 2.68; 95% confidence interval [CI] = [1.32-5.48]; P < 0.01), chills (aOR = 2.14; 95% CI = [1.13-4.11]; P < 0.01) and nausea-vomiting (aOR = 2.03; 95% CI = [1.06-3.83]; P = 0.03) were the factors associated with the occurrence of malaria. The majority of children were treated for simple malaria with artemisinin-based combination therapy. A total of 16/53 was seen in post-therapeutic consultation. Of them, 2 patients had a positive thick drop.
Non-compliance with preventive measures and the misuse of antimalarials further complicate the clinical picture, requiring parenteral management for the most part.
疟疾仍然是最致命的寄生虫病，每年在全球继续导致超过50万人死亡，主要受害者是撒哈拉以南的儿童。疟疾是儿科住院的常见原因。
目的是对法国维尔大学医院中心阿米萨·邦戈儿科的疟疾进行特征描述并描述治疗后的病情演变。
这是一项于2023年2月1日至2023年5月15日进行的横断面研究。对6个月至15岁的发热儿童进行了临床和生物学诊断。
共纳入306例患者。平均年龄为50.4±44.3个月，94.3%的患者在≥48小时内就诊，83.3%的患者进行了自我用药。疟疾患病率为17.3%。发热>39.8°C（调整后的优势比[aOR]=2.68；95%置信区间[CI]=[1.32 - 5.48]；P<0.01）、寒战（aOR = 2.14；95%CI = [1.13 - 4.11]；P<0.01）和恶心呕吐（aOR = 2.03；95%CI = [1.06 - 3.83]；P = 0.03）是与疟疾发生相关的因素。大多数儿童接受了基于青蒿素的联合疗法治疗单纯性疟疾。共有16/53例患者在治疗后进行了复诊。其中，2例患者厚血膜检查呈阳性。
不遵守预防措施和抗疟药的滥用使临床情况更加复杂，在大多数情况下需要进行肠外治疗。
