Lu Xingqi, Yu Jingtong, Ruan Litao, Numata Kazushi, Zhang Dong, Wang Feiqian
Department of Ultrasound, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.
Department of Ultrasound, Baoji Hospital of Traditional Chinese Medicine, Shaanxi, China.
Intractable Rare Dis Res. 2024 Nov 30;13(4):245-250. doi: 10.5582/irdr.2024.01032.
Post-transplant lymphoproliferative disease (PTLD) is a rare but life-threatening disease that occurs after organ transplantation. Histopathology is the gold standard for the diagnosis of PTLD. Because of its rarity and atypical symptoms, many patients are misdiagnosed with liver abscess, liver cancer, or missed diagnosis long before pathological diagnosis is obtained, thus delaying treatment. Early and accurate diagnosis, in addition to histopathological examination, is difficult. Contrast-enhanced ultrasound (CEUS) imaging techniques have overwhelming advantages of being safe (noninvasive, radiation-free) and sensitive for evaluating the microcirculation of lesions, thus making them widely used in the diagnosis of hepatic lesions. Unfortunately, there are few reports of CEUS data on hepatic PTLD (HPTLD). This study reported and analyzed four cases of HPTLD in detail, all of which underwent pre-biopsy CEUS examinations and had a complete diagnosis and treatment process. By offering readers comprehensive knowledge of CEUS in the diagnosis of HPTLD, our study aims to help reduce misdiagnoses and missed diagnoses, thereby improving patient treatment and prognosis.
移植后淋巴细胞增生性疾病（PTLD）是一种罕见但危及生命的疾病，发生于器官移植后。组织病理学是诊断PTLD的金标准。由于其罕见性和非典型症状，许多患者在获得病理诊断之前很久就被误诊为肝脓肿、肝癌或漏诊，从而延误了治疗。除组织病理学检查外，早期准确诊断也很困难。超声造影（CEUS）成像技术具有安全（无创、无辐射）和对病变微循环评估敏感的压倒性优势，因此在肝脏病变诊断中广泛应用。不幸的是，关于肝脏PTLD（HPTLD）的CEUS数据报道很少。本研究详细报告并分析了4例HPTLD病例，所有病例均在活检前进行了CEUS检查，并拥有完整的诊断和治疗过程。通过为读者提供关于CEUS在HPTLD诊断中的全面知识，我们的研究旨在帮助减少误诊和漏诊，从而改善患者的治疗和预后。
