单细胞工厂中单萜吲哚生物碱的生物生产。
Bioproduction of monoterpene indole alkaloids in a single cell factory.
作者信息
Huang Jianping, Huang Shengxiong
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
出版信息
Eng Microbiol. 2022 Oct 1;2(4):100050. doi: 10.1016/j.engmic.2022.100050. eCollection 2022 Dec.
The biosynthesis of vindoline and catharanthine, the direct precursors used for industrial production of the anti-cancer drug vinblastine, has been achieved in the yeast cell factory. To date, this is the longest natural product biosynthesis pathway that has been successfully transferred from plants to microorganisms, indicating the possibility of producing more than 3,000 other monoterpene indole alkaloids in yeast by synthetic genome engineering.
长春多灵和长春质碱是用于工业生产抗癌药物长春碱的直接前体，其生物合成已在酵母细胞工厂中实现。迄今为止，这是已成功从植物转移至微生物的最长的天然产物生物合成途径，这表明通过合成基因组工程在酵母中生产3000多种其他单萜吲哚生物碱的可能性。
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