Department of Pharmaceutical Sciences, and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, IL, USA.
Department of Pharmaceutical Sciences, and Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, IL, USA.
Curr Opin Chem Biol. 2020 Oct;58:137-145. doi: 10.1016/j.cbpa.2020.09.006. Epub 2020 Oct 29.
Natural products continue to provide privileged scaffolds for drug discovery. However, challenges in supply and structure diversification can limit development. Here, we discuss recent (2017-2020) examples of synthetic biology approaches used to address challenges in supply and contribute to structure diversification of selected plant and bacterial natural products. Our examples include plant terpenoids, alkaloids, and lignans and bacterial polyketides, nonribosomal peptides, and ribosomally synthesized and posttranslationally modified peptides.
天然产物仍然是药物发现的重要支架。然而，供应和结构多样化方面的挑战可能会限制其发展。在这里，我们讨论了最近（2017-2020 年）用于解决供应挑战并促进选定植物和细菌天然产物结构多样化的合成生物学方法的例子。我们的例子包括植物萜类、生物碱和木脂素以及细菌聚酮、非核糖体肽和核糖体合成及翻译后修饰肽。
