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硬化性黏液水肿与乳房植入物相关淋巴瘤：探究一种不寻常的临床关联。

Scleromyxedema and Breast-Implant Associated Lymphoma: Investigating an Unusual Clinical Association.

作者信息

Cline Eric, Pitchford Chase, Brady Joshua, Bari Omar, McBride Jeffrey D

机构信息

Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

出版信息

Cureus. 2024 Nov 3;16(11):e72933. doi: 10.7759/cureus.72933. eCollection 2024 Nov.

DOI:10.7759/cureus.72933
PMID:39628746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11614551/
Abstract

Scleromyxedema, a rare skin condition, is characterized by a waxy-appearing papular eruption that tends to impact middle-aged adults. Scleromyxedema is often linked to monoclonal gammopathies. However, some patients do not have a coinciding monoclonal gammopathy and experience an atypical presentation of the disease. Rarely have there been reported instances of scleromyxedema related to lymphoma. In this case report, we present a woman being evaluated for breast-implant-associated anaplastic large cell lymphoma (BIA-ALCL) who ultimately received the diagnosis of scleromyxedema.

摘要

硬化性黏液水肿是一种罕见的皮肤病，其特征为出现蜡样丘疹性皮疹，多见于中年成年人。硬化性黏液水肿常与单克隆丙种球蛋白病相关。然而，一些患者并无同时存在的单克隆丙种球蛋白病，而是经历了该病的非典型表现。与淋巴瘤相关的硬化性黏液水肿病例鲜有报道。在本病例报告中，我们介绍了一名因乳房植入物相关间变性大细胞淋巴瘤（BIA-ALCL）接受评估的女性，最终被诊断为硬化性黏液水肿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/08469dc6807d/cureus-0016-00000072933-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/3de2b73a696a/cureus-0016-00000072933-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/0005111a10cd/cureus-0016-00000072933-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/05461fbf28d1/cureus-0016-00000072933-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/d732dcc9820e/cureus-0016-00000072933-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/08469dc6807d/cureus-0016-00000072933-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/3de2b73a696a/cureus-0016-00000072933-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/0005111a10cd/cureus-0016-00000072933-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/05461fbf28d1/cureus-0016-00000072933-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/d732dcc9820e/cureus-0016-00000072933-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/801f/11614551/08469dc6807d/cureus-0016-00000072933-i05.jpg

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本文引用的文献

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Breast Implant-associated Anaplastic Large Cell Lymphoma.乳房植入物相关间变性大细胞淋巴瘤
Clin Lymphoma Myeloma Leuk. 2021 Mar;21(3):e272-e276. doi: 10.1016/j.clml.2020.12.005. Epub 2020 Dec 13.
2
Scleromyxedema treatment: a systematic review and update.硬肿性黏液水肿的治疗：系统评价与更新。
Int J Dermatol. 2020 Oct;59(10):1191-1201. doi: 10.1111/ijd.14888. Epub 2020 May 2.
3
Plasma cell-directed therapies in monoclonal gammopathy-associated scleromyxedema.浆细胞靶向治疗在单克隆丙种球蛋白病相关硬皮黏液水肿中的应用。
Blood. 2020 Apr 2;135(14):1101-1110. doi: 10.1182/blood.2019002300.
4
Monoclonal Gammopathy of Undetermined Significance-associated Scleromyxoedema.意义未明的单克隆丙种球蛋白病相关性硬化性黏液水肿
Indian Dermatol Online J. 2019 Jan-Feb;10(1):54-57. doi: 10.4103/idoj.IDOJ_138_18.
5
Paraneoplastic atypical scleromyxedema with advanced gastric cancer.副肿瘤性非典型硬化性黏液水肿伴晚期胃癌
JAAD Case Rep. 2017 Aug 12;3(5):376-378. doi: 10.1016/j.jdcr.2017.04.005. eCollection 2017 Sep.
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High-dose intravenous immunoglobulin therapy for scleromyxoedema: a prospective open-label clinical trial using an objective score of clinical evaluation system.大剂量静脉注射免疫球蛋白治疗硬肿性黏液水肿：采用客观临床评估系统评分的前瞻性开放性临床试验。
J Eur Acad Dermatol Venereol. 2017 Jul;31(7):1157-1160. doi: 10.1111/jdv.14244. Epub 2017 Apr 12.
7
Scleromyxedema: a multicenter study of characteristics, comorbidities, course, and therapy in 30 patients.硬肿性黏液水肿：30 例患者的特征、合并症、病程和治疗的多中心研究。
J Am Acad Dermatol. 2013 Jul;69(1):66-72. doi: 10.1016/j.jaad.2013.01.007. Epub 2013 Feb 26.
8
Scleromyxedema.
Clin Dermatol. 2006 Nov-Dec;24(6):493-7. doi: 10.1016/j.clindermatol.2006.07.011.
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Lichen myxedematosus (papular mucinosis): new concepts and perspectives for an old disease.黏液水肿性苔藓（丘疹性黏蛋白病）：一种古老疾病的新概念与新视角
Semin Cutan Med Surg. 2006 Jun;25(2):100-4. doi: 10.1016/j.sder.2006.04.001.
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Scleromyxedema: possible association with seminoma.
J Am Acad Dermatol. 2000 May;42(5 Pt 2):875-8. doi: 10.1016/s0190-9622(00)90259-7.