Salucci Sara, Hitrec Timna, Piscitiello Emiliana, Occhinegro Alessandra, Alberti Luca, Taddei Ludovico, Burattini Sabrina, Luppi Marco, Tupone Domenico, Amici Roberto, Faenza Irene, Cerri Matteo
Department of Biomedical and Neuromotor Sciences - University of Bologna, Bologna, Italy.
Department of Biomolecular Sciences, Carlo Bo Urbino University, Urbino, Italy.
Front Physiol. 2024 Nov 19;15:1451644. doi: 10.3389/fphys.2024.1451644. eCollection 2024.
Torpor is a state used by several mammals to survive harsh winters and avoid predation, characterized by a drastic reduction in metabolic rate followed by a decrease in body temperature, heart rate, and many physiological variables. During torpor, all organs and systems must adapt to the new low-energy expenditure conditions to preserve physiological homeostasis. These adaptations may be exploited in a translational perspective in several fields. Recently, many features of torpor were shown to be mimicked in non-hibernators by the inhibition of neurons within the brainstem region of the Raphe Pallidus. The physiological resemblance of this artificial state, called synthetic torpor, with natural torpor has so far been described only in physiological terms, but no data have been shown regarding the induced morphological changes. Here, we show the first description of the ultrastructural changes in the liver, kidney, lung, skeletal muscle, and testis induced by a 6-hours inhibition of Raphe Pallidus neurons in a non-hibernating species, the rat.
蛰伏是几种哺乳动物用来度过严冬并避免被捕食的一种状态，其特征是代谢率急剧下降，随后体温、心率和许多生理变量也随之降低。在蛰伏期间，所有器官和系统都必须适应新的低能量消耗状态，以维持生理稳态。这些适应性变化可以从转化医学的角度在多个领域加以利用。最近研究表明，通过抑制中缝苍白核脑干区域内的神经元，非冬眠动物可以模拟出蛰伏的许多特征。到目前为止，这种被称为合成蛰伏的人工状态与自然蛰伏在生理方面的相似性仅在生理层面有所描述，但尚未有关于其诱导形态变化的数据。在此，我们首次描述了在非冬眠物种大鼠中，通过抑制中缝苍白核神经元6小时所诱导的肝脏、肾脏、肺、骨骼肌和睾丸的超微结构变化。
