Govaerts Jeroen, Verluyten Annelies, Bouckaert Filip, De Hert Marc A F, Desplenter Franciska A M
University Psychiatric Center KU Leuven, Z.org KU Leuven, Kerkstraat 12, Kuurne 8520, Belgium.
University Psychiatric Center KU Leuven, Z.org KU Leuven, Kortenberg, Belgium.
Ther Adv Drug Saf. 2024 Dec 2;15:20420986241233842. doi: 10.1177/20420986241233842. eCollection 2024.
Clozapine, an antipsychotic used in the treatment of schizophrenia, is known for its serious side effects. In order to promote patient safety, drug-drug interaction (DDI) databases can be consulted by clinicians. In this study, the degree of consensus between five sources on DDIs with clozapine is determined.
The summary of product characteristics of clozapine, Delphicare interaction database, Stockley's interaction checker, the Lexicomp interaction database, and the interaction database of Clinical Pharmacology are included. By comparing the original categories assigned to interactions with clozapine by the included DDI sources, a degree of consensus between sources is determined. Furthermore, based on the combined information, an evaluation on the severity of each potential interaction is made.
One hundred eighty-three potential DDIs with clozapine are retrieved from the five included sources. A consensus between sources is found in 47.5% ( = 87) of DDIs.
This study shows major discrepancies between five different sources on DDIs with clozapine. The potential impact of the use of one specific database on patient safety and prescribing behavior could prove to be problematic.
氯氮平是一种用于治疗精神分裂症的抗精神病药物，以其严重的副作用而闻名。为了提高患者安全性，临床医生可以查阅药物相互作用（DDI）数据库。在本研究中，确定了五个来源关于氯氮平药物相互作用的共识程度。
纳入氯氮平的产品特征摘要、Delphicare相互作用数据库、Stockley相互作用检查器、Lexicomp相互作用数据库以及临床药理学相互作用数据库。通过比较所纳入的DDI来源对与氯氮平相互作用所指定的原始类别，确定来源之间的共识程度。此外，基于综合信息，对每种潜在相互作用的严重程度进行评估。
从五个纳入来源中检索到183种与氯氮平潜在的药物相互作用。在47.5%（n = 87）的药物相互作用中发现了来源之间的共识。
本研究表明，五个不同来源关于氯氮平药物相互作用存在重大差异。使用一个特定数据库对患者安全性和处方行为的潜在影响可能会出现问题。
