Berjawi Ahmad, Saade Namir, Tannous Zeina
Department of Dermatology, Gilbert and Rose Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon.
J Skin Cancer. 2024 Nov 26;2024:2696706. doi: 10.1155/jskc/2696706. eCollection 2024.
Skin cancer is the most common cancer worldwide. According to the Skin Cancer Foundation, Mohs micrographic surgery (MMS) is considered the most effective technique for treating nonmelanoma skin cancer (NMSC). Recurrence rate after MMS for treating NMSC ranges from 1.4% to 3.2% for primary tumors and 2.4%-6% for recurrent tumors. The aim of the study was to report data from a tertiary care center in Lebanon providing MMS to patients with NMSC. Retrospective cohort study was conducted through chart review of 94 patients at the Lebanese American University Medical Center (LAUMC-RH) with a total of 115 cases of MMS identified. The study showed that most cases were males (72; 63%), and 77% were aged > 60 years (88). The average tumor size was 1.6 cm. Recurrence rate was zero in primary tumors and 0.9% in recurrent tumors. With respect to age, bivariate analysis showed that cases of males over 60 years of age were more significantly associated with undergoing Mohs surgery (69% vs. 31%; =0.012). With respect to maximum tumor diameter (MTD) > 1 cm, male gender was associated with a higher MTD when compared to females (74% vs. 26%; =0.02). Also, Area L was associated with a larger MTD when compared to areas H and M, respectively (90% vs. 61.1% vs. 37.7%; =0.01). Multivariate analysis of MTD showed that tumors with MTD > 1 cm were significantly associated with male gender, presence in low- or middle-risk areas and being a recurrent tumor. This study shows that MMS is adequate for the treatment of NMSC at our center with minimal complications (< 1%) and recurrence (< 1%).
皮肤癌是全球最常见的癌症。根据皮肤癌基金会的说法,莫氏显微外科手术(MMS)被认为是治疗非黑色素瘤皮肤癌(NMSC)最有效的技术。MMS治疗NMSC后,原发性肿瘤的复发率为1.4%至3.2%,复发性肿瘤的复发率为2.4% - 6%。本研究的目的是报告黎巴嫩一家三级医疗中心为NMSC患者提供MMS的数据。通过对黎巴嫩美国大学医学中心(LAUMC - RH)的94例患者进行病历回顾,共确定了115例MMS病例,进行了回顾性队列研究。研究表明,大多数病例为男性(72例;63%),77%的患者年龄大于60岁(88例)。肿瘤平均大小为1.6厘米。原发性肿瘤的复发率为零,复发性肿瘤的复发率为0.9%。关于年龄,双变量分析显示,60岁以上男性病例与接受莫氏手术的相关性更显著(69%对31%;P = 0.012)。关于最大肿瘤直径(MTD)> 1厘米,与女性相比,男性性别与更大的MTD相关(74%对26%;P = 0.02)。此外,与区域H和M相比,区域L分别与更大的MTD相关(90%对61.1%对37.7%;P = 0.01)。MTD的多变量分析显示,MTD > 1厘米的肿瘤与男性性别、存在于低风险或中等风险区域以及为复发性肿瘤显著相关。本研究表明,MMS在我们中心治疗NMSC是足够的,并发症最少(< 1%)且复发率低(< 1%)。