Vajdi Tina, Eilers Robert, Jiang Shang I Brian
Department of Dermatology, School of Medicine, University of California , San Diego, CA, USA.
Department of Dermatology, Dermatologic and Mohs Micrographic Surgery Center, School of Medicine, University of California San Diego, CA, USA.
J Clin Investig Dermatol. 2017 Jan;5(1). doi: 10.13188/2373-1044.1000036. Epub 2017 Jan 10.
Mohs micrographic surgery (MMS) is used to treat certain high-risk non-melanoma skin cancers (NMSC) due to its high cure rate. However, clinical recurrences do occur in a small number of cases.
We examined specific clinical characteristics associated with NMSC recurrences following MMS.
We employed a retrospective chart review of the 1467 cases of NMSC that underwent MMS at UC San Diego from January 1, 2008 through December 31, 2009. A total of 356 cases were excluded due to lack of follow-up.
Five (0.45%) of 1111 cases developed recurrences of NMSC at the site of MMS. There were 741 cases of basal cell carcinomas (BCC); 3 were recurrences (0.40%). There were 366 cases of squamous cell carcinomas (SCC); 2 were recurrences (0.55%). Review of MMS histopathology of these recurrent tumors showed that there were no errors or difficulty with the processing or interpretation of the slides.
Five-year recurrence rate of NMSC following MMS at our institution is below the reported average. Our retrospective chart review identified specific clinical characteristics associated with NMSC recurrence including a history of smoking, anatomical location on the cheeks, ears or nose, and a history of immunosuppression for SCCs.
莫氏显微外科手术（MMS）因其高治愈率而用于治疗某些高危非黑色素瘤皮肤癌（NMSC）。然而，少数病例确实会出现临床复发。
我们研究了MMS术后NMSC复发相关的特定临床特征。
我们对2008年1月1日至2009年12月31日在加州大学圣地亚哥分校接受MMS治疗的1467例NMSC病例进行了回顾性病历审查。由于缺乏随访，共排除356例病例。
1111例病例中有5例（0.45%）在MMS手术部位出现NMSC复发。基底细胞癌（BCC）741例，其中3例复发（0.40%）。鳞状细胞癌（SCC）366例，其中2例复发（0.55%）。对这些复发性肿瘤的MMS组织病理学检查显示，切片处理或解读不存在错误或困难。
在我们机构，MMS术后NMSC的五年复发率低于报告的平均水平。我们的回顾性病历审查确定了与NMSC复发相关的特定临床特征，包括吸烟史、脸颊、耳朵或鼻子的解剖位置，以及SCC的免疫抑制史。
