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先天性心脏病患者的复杂主动脉瓣修复:临床反馈

Complex aortic valve repair in congenital patients: clinical feedback.

作者信息

Barbier Marie-Anne, Bulescu Nicolae Cristian, Metton Olivier, Bou Karam Lea, Martin Bonnet Caroline, Moulin Zinsch Anne, Lilot Marc, Henaine Roland

机构信息

Congenital Cardiac Surgery, Louis Pradel Hospital, Lyon, France.

Pediatric and Congenital Cardiology Department, Hopital Louis Pradel, Lyon, France.

出版信息

Front Pediatr. 2024 Nov 19;12:1466311. doi: 10.3389/fped.2024.1466311. eCollection 2024.

Abstract

INTRODUCTION

In the congenital population, particularly in young adults, the best strategy for aortic valve surgery has not been clearly established. This study investigates the mortality, perioperative morbidity and echocardiographic evolution of complex aortic valve repair techniques.

MATERIAL AND METHODS

We performed a retrospective monocentric descriptive study of patients operated at the Louis Pradel Hospital (Lyon) from 2017 to 2023. We included patients operated for complex aortic valve repair by the congenital heart surgery team, excluding simple commissurotomies. The primary endpoint was postoperative survival. The secondary endpoints were freedom from surgical reintervention and echocardiographic evolution of aortic regurgitation, aortic stenosis and annular diameter. The analysis was performed using Kaplan Meier methods.

RESULTS

Twenty-eight patients were included. The mean age was 11.1 years (range 1-35 years) and the mean weight was 37.5 kg (range 8.2-79 kg). The postoperative survival rate was 96.4% at discharge (27/28 patients). The mean follow-up interval was 35 months (range 14-79 months). At the end of the follow-up, the freedom from reoperation was 85.7%. Four patients underwent reoperation for worsening aortic valve and/or ventricular function (1 heart transplantation, 2 Ross procedures, 1 aortic valve replacement). Results on secondary endpoints showed a trend towards improvement in annular diameter postoperatively between pre- and postoperative echocardiography for each patient, with no statistically significant difference for aortic insufficiency, but for aortic stenosis ( = 0.02).

CONCLUSION

This study shows an excellent survival rate, and a similar risk of reintervention compared with literature data. All the data described above argue in favor of an aortic valve repair surgery as a first line procedure in case of congenital heart disease.

摘要

引言

在先天性心脏病患者群体中,尤其是年轻成年人,主动脉瓣手术的最佳策略尚未明确确立。本研究调查了复杂主动脉瓣修复技术的死亡率、围手术期发病率及超声心动图演变情况。

材料与方法

我们对2017年至2023年在路易·普拉德尔医院(里昂)接受手术的患者进行了一项回顾性单中心描述性研究。我们纳入了由先天性心脏病手术团队进行复杂主动脉瓣修复手术的患者,不包括单纯的交界切开术。主要终点是术后生存率。次要终点是免于再次手术以及主动脉瓣反流、主动脉瓣狭窄和瓣环直径的超声心动图演变情况。分析采用Kaplan Meier方法。

结果

纳入28例患者。平均年龄为11.1岁(范围1 - 35岁),平均体重为37.5千克(范围8.2 - 79千克)。出院时术后生存率为96.4%(27/28例患者)。平均随访间隔为35个月(范围14 - 79个月)。随访结束时,免于再次手术的比例为85.7%。4例患者因主动脉瓣和/或心室功能恶化接受了再次手术(1例心脏移植、2例罗斯手术、1例主动脉瓣置换)。次要终点结果显示,每位患者术前和术后超声心动图检查之间瓣环直径术后有改善趋势,主动脉瓣关闭不全无统计学显著差异,但主动脉瓣狭窄有统计学显著差异(P = 0.02)。

结论

本研究显示出优异的生存率,且再次干预风险与文献数据相似。上述所有数据均支持在先天性心脏病情况下将主动脉瓣修复手术作为一线手术方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbdb/11613884/f46610c7baaf/fped-12-1466311-g001.jpg

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