Portero Carolina E, Han Yong, Marchán-Rivadeneira M Raquel
Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA.
Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Eng Microbiol. 2022 Dec 13;3(2):100064. doi: 10.1016/j.engmic.2022.100064. eCollection 2023 Jun.
Numerous studies have investigated the biosynthesis of pyridine heterocycles derived from nicotinic acid. However, metabolic pathways generating pyridine heterocycles in nature remain uninvestigated. Here, we summarize recent contributions conducted in the last decade on the biosynthetic pathways of non-derivate from nicotinic acid pyridine rings and discuss their implication on the study of natural products with pyridine structures.
许多研究已经探究了源自烟酸的吡啶杂环的生物合成。然而,自然界中产生吡啶杂环的代谢途径仍未得到研究。在此,我们总结了过去十年中关于非烟酸衍生吡啶环生物合成途径的最新研究成果,并讨论了它们对具有吡啶结构的天然产物研究的意义。