Zhu Zhouhai, Wang Meng, Guan Ying, Li Meng, Peng Qiyuan, Zheng Ning, Ma Wenbin
Joint Institute of Tobacco and Health, Kunming 650106, China.
State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, China.
Eng Microbiol. 2024 Jan 18;4(2):100138. doi: 10.1016/j.engmic.2024.100138. eCollection 2024 Jun.
The association between cigarette smoking and the gut microbiota remains unclear, and there is no agreement on how smoking affects the composition of gut microorganisms. In this study, the relationship between smoking status and gut microbial composition was investigated by performing 16S rRNA gene amplicon sequencing analysis of stool samples from 80 healthy Chinese adults. The results showed that smoking did not cause significant changes to the composition and microbial functional pathways of the gut microbiota. However, smoking altered the relative abundance of several specific taxa, where and increased and decreased. Notably, our analysis revealed that smoking introduced more microbial interactions to the interaction network and decreased its modularity. Overall, this study provides new insights into the association between smoking status and the gut microbiota.
吸烟与肠道微生物群之间的关联仍不明确，对于吸烟如何影响肠道微生物组成也尚未达成共识。在本研究中，通过对80名健康中国成年人的粪便样本进行16S rRNA基因扩增子测序分析，研究了吸烟状况与肠道微生物组成之间的关系。结果表明，吸烟并未导致肠道微生物群的组成和微生物功能途径发生显著变化。然而，吸烟改变了几种特定分类群的相对丰度，其中[具体分类群1]和[具体分类群2]增加，[具体分类群3]减少。值得注意的是，我们的分析表明，吸烟给相互作用网络引入了更多的微生物相互作用，并降低了其模块化程度。总体而言，本研究为吸烟状况与肠道微生物群之间的关联提供了新的见解。
