Denis Manon, Lauzier Benjamin, Roumeliotis Nadia, Orliaguet Gilles, Emeriaud Guillaumes, Javouhey Etienne, Brossier David
Pediatric Intensive Care Unit, CHU de Caen, Caen, France.
Pediatric Intensive Care Unit, CHU de Nantes, Nantes, France.
J Pediatr Intensive Care. 2022 Apr 8;13(4):389-398. doi: 10.1055/s-0042-1744298. eCollection 2024 Dec.
Best strategies for managing severe pediatric traumatic brain injury (TBI) are not established, with wide variations among professional practices. The main objective of this study was to assess compliance with updated pediatric TBI management guidelines (2019). A survey was distributed among French-speaking pediatric intensive care physicians from April 1 to June 30, 2019. The survey was based on a clinical case with a total of 70 questions that cover the 15 items of the 2019 TBI guidelines. The questions evaluated the assessment and management of TBI during the acute and intensive care phases. Of 487 e-mails sent, 78 surveys were included. Guidelines were adhered to (> 60%) for 10 of 15 items in the guidelines. Strong adherence to recent guideline changes was achieved for seizure prophylaxis with levetiracetam ( = 21/33, 64%) and partial pressure of carbon dioxide threshold ( = 52, 67%). However, management of the sodium and glucose thresholds and the role of transcranial Doppler were not consistent with the guidelines. Assessment of brain tissue oxygenation ( = 12, 16%) and autoregulation ( = 35, 45%) was not a common practice. There was strong agreement among clinicians on the intracranial pressure (> 80%) and cerebral perfusion pressure (> 70%) thresholds used according to age. Overall, stated practices for the management of TBI appear to be relatively standardized among responders. Variations persist in areas with a lack of evidence and pediatric-specific recommendations.
目前尚未确定管理儿童重度创伤性脑损伤(TBI)的最佳策略,专业实践之间存在很大差异。本研究的主要目的是评估对更新后的儿童TBI管理指南(2019年)的依从性。2019年4月1日至6月30日期间,向说法语的儿科重症监护医生发放了一份调查问卷。该调查问卷基于一个临床病例,共有70个问题,涵盖了2019年TBI指南的15项内容。这些问题评估了TBI在急性和重症监护阶段的评估和管理。在发送的487封电子邮件中,纳入了78份调查问卷。指南中15项内容中的10项得到了遵循(>60%)。对于使用左乙拉西坦预防癫痫( = 21/33,64%)和二氧化碳分压阈值( = 52,67%),对近期指南变化的依从性较高。然而,钠和葡萄糖阈值的管理以及经颅多普勒的作用与指南不一致。脑组织氧合评估( = 12,16%)和自动调节评估( = 35,45%)并不常见。临床医生对于根据年龄使用的颅内压(>80%)和脑灌注压(>70%)阈值达成了强烈共识。总体而言,在受访者中,TBI的既定管理实践似乎相对标准化。在缺乏证据和针对儿科的建议的领域,差异仍然存在。